Study identifies new tumor suppressor gene in Li-Fraumeni syndrome

In 1990 a research team based at the Massachusetts General Hospital (MGH) discovered the gene responsible for most cases of Li-Fraumeni syndrome, a rare inherited condition that leads to the frequent occurrence of several types of cancer in affected families. That gene - p53 - subsequently has proven to be one of the most important genes involved in the development of human cancer. In addition to the gene's role in Li-Fraumeni, non-inherited mutations to p53 are found in half of all human tumors.

Now a team based in the same MGH research lab has identified another gene that is mutated in some families that, without having p53 mutations, appear to have Li-Fraumeni or a closely related syndrome. Like p53 the new gene, called CHK2, appears to play a key role in the cell cycle, the process by which cells grow and divide. Both genes control checkpoints at which cells with damaged DNA should either repair themselves or stop growing, avoiding the development of cancer.

"We have found that CHK2 is a tumor suppressor gene that, when mutated, produces effects similar to those of p53 mutations. The evidence suggests it is part of the same pathway for controlling cell growth and replication," says Daniel Haber, MD, PhD, director of Cancer Risk Analysis at the MGH and leader of the study, which appears in the Dec. 24 issue of Science.

Li-Fraumeni syndrome was first described in 1969 by Frederick Li, MD, now at Dana Farber Cancer Institute, and Joseph Fraumeni, MD, of the National Cancer Institute - both of whom are co-authors of the current study. The rare condition was one of the first instances in which increased vulnerability to several types of adult cancers was clearly inherited. Identification of the tumor suppressor role of p53, along with its role in the cell cycle, directly connected a breakdown in the cell cycle with the development of cancer. It also opened up a search for other inherited cancer-related genes. Among areas in which subsequen

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:

(Date:11/19/2019)... YORK (PRWEB) , ... November 19, 2019 , ... The ... Plaza Times Square in New York City. The one-day event will be chaired by ... group of leaders in the space. , “We are witnessing significant innovation in ...
(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman ... regulatory affairs and program management executive with more than 33 years of regulatory ... the firm as an Expert Consultant. , Robert Peterson has extensive experience ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... medical devices, today announced the creation of a Global Regulatory Affairs Department, to ... Device industry is that the regulatory element to any Medtech organization is more ...
Breaking Biology News(10 mins):
(Date:12/2/2019)... ... ... Registration is now open for the American Society of Gene & Cell ... May 12-15, 2020, in Boston. The meeting is the premier event in the field ... stakeholders with the goal of advancing gene and cell therapies to alleviate human disease. ...
(Date:11/20/2019)... ... November 20, 2019 , ... ... of about 8,500 microturbine electrical power generation units from 2019-2028. The value of ... over 2017's projection of 3,821 units worth $569 million. , Reference to ...
(Date:11/12/2019)... Wis. (PRWEB) , ... November 12, 2019 , ... ... food ingredient solutions for the food and beverage industry launched a new innovative ... improve the digital experience. Now, the website offers global visitors updated ingredient usage ...
(Date:11/6/2019)... ... ... Diversified Technologies, Inc. has introduced a PEF production system for ... processing. , The DTI Industrial PEF Unit can pre-treat whole pieces of fruits and ... up to 50% and achieve up to an 80% reduction of drying energy. ...
Breaking Biology Technology:
Cached News: