HOME >> BIOLOGY >> NEWS
Study links amyloid plaques in Alzheimer's brains to genes vital to normal memory

Tampa, FL (June 27, 2003) -- The buildup of Alzheimer's-associated amyloid plaques in the brain dramatically inhibits several genes critical to memory and learning, University of South Florida College of Medicine researchers have found.

The strong link between the decreases in select memory genes and amyloid accumulation was observed both in mice genetically engineered to develop memory loss and in the brains of deceased Alzheimer's patients. The results are reported in the June 15 issue of the Journal of Neuroscience published online today.

"Blocking the ability of amyloid to inhibit, or down-regulate, these genes may improve memory in patients with early Alzheimer's disease," said principal investigator David Morgan, PhD, professor of pharmacology and therapeutics and director of the Alzheimer's Disease Research Laboratory at USF.

Many experimental approaches to treating Alzheimer's disease, including the vaccine, try to prevent the further formation of amyloid plaques or remove some of them from the brain. But, Dr. Morgan said, by the time memory loss becomes apparent the toxic plaques are probably accumulating too quickly to eliminate enough amyloid needed to restore normal memory.

"Our study suggests a new approach to treating this neurodegenerative disease that would enhance amyloid-lowering approaches," he said. "For instance, you might give a vaccine or some other immune therapy to reduce the amyloid load and then start the patient on a memory-enhancing drug to block the effect of any remaining amyloid on normal learning and memory."

"This interrogation of the genome reveals new targets for both study and intervention," says D. Stephen Snyder, Ph.D., of the Etiology of Alzheimer's Disease-Cell Biology area of the National Institute on Aging, which funded the research. "This study addresses the important question of what genes related to learning and memory are regulated either up or down by amyloid."

Loss
'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
26-Jun-2003


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
(Date:8/5/2020)... ... 05, 2020 , ... Regenative Labs has received approval from the Centers for ... them the first Wharton’s jelly allografts to be assigned a Q code and be ... the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P by ...
(Date:7/22/2020)... , ... July 21, 2020 , ... ... transformation and innovation in technology and compliance, announces a new solution to manage ... must ensure every layer of their technology stack complies with FDA and global ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... 200 of the top radiation centers in 16 countries, has reached its 20th ... SDX® is now in routine use at top universities including University of Pennsylvania, ...
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said ... on the market and we were pleased that the IFT jury recognized that.” reFRESH™ ... creating a natural way to extend the shelf life and improve the safety of ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra ... life sciences and food industries, is pleased to announce that Charles Galea has ... Business Development. , Charles is an accomplished and results-driven sales executive with over ...
Breaking Biology Technology:
Cached News: