HOME >> BIOLOGY >> NEWS
Study links amyloid plaques in Alzheimer's brains to genes vital to normal memory

of recent memory is one of the first symptoms of Alzheimer's disease, occurring years before enough nerve cells are choked off to cause disability and death. The USF researchers were trying to determine what triggers this early memory loss if neurons and their connections are still intact.

They used a technique known as microarray analysis to simultaneously screen thousands of genes from brain tissue of mice bred to develop Alzheimer's-associated amyloid plaques. A second more specific technique, quantatitive reverse transcriptase polymerase chain reaction, confirmed the study results.

Six of at least 30 known genes associated with memory and learning were dramatically reduced, or down-regulated, in the mouse model for Alzheimer's disease when compared to the control mice with normal memory. Furthermore, in the mouse model these six genes were signficantly decreased in regions of the brain containing amyloid, the hippocampus and cerebral cortex, but remained unchanged in amyloid-free regions of the brain.

The researchers then compared their findings in the mouse model with an analysis of human Alzheimer's disease tissue from the Brain Donation Program at Sun Health Research Institute in Sun City, AZ.

The same six memory-associated genes reduced in the mousel model for Alzheimer's -- Arc, Zif268, NR2B, GluR1, Homer-1a and Nur77/TR3 -- were also significantly underexpressed in the amyloid-containing regions of brains from deceased Alzheimer's patients. In the the amyloid-free regions of the human brains, the genes again remained unchanged.

Furthermore in the human brains, unlike the mouse brains, all genes related to neural activity were reduced, likely because the human tissue was littered with dead nerve cells characteristic of late-stage Alzheimer's disease, Dr. Morgan said.

The collective evidence strongly suggests that the start of amyloid deposits in the brain selectively reduces expression of a group of gene
'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
26-Jun-2003


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... Inc. (NASDAQ: AWRE ), a leading supplier of biometrics software ... year ended December 31, 2015.  --> ... $6.9 million, an increase of 61% compared to $4.3 million in ... of 2015 was $2.6 million compared to $0.2 million in the ... --> Higher revenue and operating income in the fourth quarter ...
(Date:2/8/2016)... 2016 Worldcore is ... innovation for clients, comfort and unbeatable security, with ... --> Worldcore is the first EU-regulated ... comfort and unbeatable security, with a Voice Biometrics ... Worldcore is the first EU-regulated global payment ...
(Date:2/4/2016)... , Feb. 4, 2016 The ... apparently one of the most popular hubs of ... MetaHIT and other huge studies of human microbiota, ... past few years, the microbiome space has literally ... biomedical research. This report focuses on biomedical ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... ... that it has joined the Human Vaccines Project, a public-private partnership to ... cancer. , The Human Vaccines Project brings together leading pharmaceutical and ...
(Date:2/10/2016)... 10, 2016  Matchbook, Inc., a company specializing ... biotech companies, announced today the appointment of ... Jim brings nearly 25 years of experience in ... spent nearly two decades in executive level roles ... at Genzyme and, most recently headed global logistics ...
(Date:2/10/2016)... NY (PRWEB) , ... February 10, 2016 , ... LATHAM, ... packages at the SPIE Photonics West conference in San Francisco’s Moscone Center ... 14 in the same venue. , These latest InGaAs PIN diode standard packages ...
(Date:2/10/2016)... MA (PRWEB) , ... February 10, 2016 , ... ... is now available on Microsoft Azure. On Azure, Arvados provides capabilities for managing ... saw clear demand for Microsoft Azure from major institutions collecting and analyzing genomic ...
Breaking Biology Technology:
Cached News: