HOME >> BIOLOGY >> NEWS
Study links amyloid plaques in Alzheimer's brains to genes vital to normal memory

of recent memory is one of the first symptoms of Alzheimer's disease, occurring years before enough nerve cells are choked off to cause disability and death. The USF researchers were trying to determine what triggers this early memory loss if neurons and their connections are still intact.

They used a technique known as microarray analysis to simultaneously screen thousands of genes from brain tissue of mice bred to develop Alzheimer's-associated amyloid plaques. A second more specific technique, quantatitive reverse transcriptase polymerase chain reaction, confirmed the study results.

Six of at least 30 known genes associated with memory and learning were dramatically reduced, or down-regulated, in the mouse model for Alzheimer's disease when compared to the control mice with normal memory. Furthermore, in the mouse model these six genes were signficantly decreased in regions of the brain containing amyloid, the hippocampus and cerebral cortex, but remained unchanged in amyloid-free regions of the brain.

The researchers then compared their findings in the mouse model with an analysis of human Alzheimer's disease tissue from the Brain Donation Program at Sun Health Research Institute in Sun City, AZ.

The same six memory-associated genes reduced in the mousel model for Alzheimer's -- Arc, Zif268, NR2B, GluR1, Homer-1a and Nur77/TR3 -- were also significantly underexpressed in the amyloid-containing regions of brains from deceased Alzheimer's patients. In the the amyloid-free regions of the human brains, the genes again remained unchanged.

Furthermore in the human brains, unlike the mouse brains, all genes related to neural activity were reduced, likely because the human tissue was littered with dead nerve cells characteristic of late-stage Alzheimer's disease, Dr. Morgan said.

The collective evidence strongly suggests that the start of amyloid deposits in the brain selectively reduces expression of a group of gene
'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
26-Jun-2003


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
(Date:4/13/2015)... a leading cloud-based consumer engagement platform that provides trusted ... communities around health and wellness, announced today the launching ... The ... vehicle to receive validated health information from consumers. ... will allow higi,s trusted partners, on a user opt-in ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... solutions, announced today that it will report financial results ... April 23, 2015, after the close of market. The ... and investors at 2:00 p.m. PT (5:00 p.m. ET), ... To participate on the live call, analysts and ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
(Date:4/21/2015)... ENGLEWOOD, Colo. , April 21, 2015 ... details for a scheduled investor call on Thursday, April ... in using the instructions as follows: ... toll-free number: (844) 789-4877 International toll number: (925) ... emailed in advance to Tina Amirkiai , ...
(Date:4/21/2015)... , April 21, 2015  Tute Genomics, a leading ... of Josh Forsythe as VP of Marketing. Mr. ... witnessed a significant expansion in its commercial operations over the ... " Josh Forsythe is a tremendous addition ... MD MBA, CEO of Tute Genomics. "Josh,s vast experience commercializing ...
(Date:4/21/2015)... April 21, 2015 PRC Clinical, ... and exhibit at the ACRP 2015 Global Conference and ... Utah. The Association of Clinical Research Professionals (ACRP) Global ... conference solely focused on the conduct of clinical trials. ... development, and widely recognized industry certifications. , The ...
(Date:4/21/2015)... Cleveleys (UK) (PRWEB) April 21, 2015 ... technology and its clinical applications will be ... Participants include engineers, scientists, regulators and clinicians ... The meeting is sponsored by Invibio Biomaterial ... polymer-based biomaterials, a specialist in manufacturing and ...
Breaking Biology Technology:Ampio Announces Investor Call on Thursday, April 23, 4:30 p.m. ET 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 2Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 3Tute Genomics Continues Expansion of Genomic Medicine Commercial Operations; Appoints Josh Forsythe as New VP of Marketing 4PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 22nd International PEEK Meeting: Invibio Biomaterial Solutions spearheads medical research for implantable PEEK polymer devices 3
Cached News: