HOME >> BIOLOGY >> NEWS
Study may direct solutions for air pollution disease affecting agricultural, industrial workers

(December 17, 2002) Bethesda, MD Infiltration of airway mucus with inflammatory cells is thought to be a key factor in the cause of airway disorders, including asthma and chronic bronchitis. At the same time, neutrophils ["polymorphonuclear leukocytes" or (PMNs)] contribute to the immune response of the airway to infectious and noninfectious irritants. Although it is usually protective and beneficial, this response to the threat of inflammation has the potential to cause tissue injury.

Background

Neutrophils that respond to airway inflammation cause tissue damage via the production and release of oxygen radicals, proteases, and soluble mediators of inflammation. Inhaled irritants such as cigarette smoke, ozone, and bacterial endotoxin can produce inflammation through nonallergic mechanisms. Endotoxin [or lipopolysaccharide (LPS)], a component of the cell wall of gram-negative bacteria, is ever-present in the environment, with high concentrations in organic dusts, such as dust from grain, and air-pollution particles.

Several studies have demonstrated that inhalation of air that is contaminated with endotoxin is associated with the classic features of asthma, including reversible airflow obstruction and inflammation and persistent airway hyperreactivity and remodeling. Epidemiological studies have shown that the concentration of inhaled endotoxin in the air is strongly and consistently associated with reversible airflow obstruction among cotton workers, agricultural workers, and fiberglass workers.

Previous studies have shown that the concentration of endotoxin in the air is the most important occupational exposure associated with airway disease found in agricultural workers. Experimentally, inhalation of endotoxin can cause reversible airflow obstruction and airway inflammation in previously unexposed healthy study subjects. In fact, healthy study subjects challenged with dust from animal-confinement buildings develop airflow
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
17-Dec-2002


Page: 1 2 3 4 5

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... ... June 04, 2020 , ... Greffex, a pioneering vaccine and ... of Directors. , “Neil understands the need for a global perspective to make an ... of Greffex. Mr. Bush will serve as an independent, director of the company. , ...
(Date:5/28/2020)... ... May 27, 2020 , ... Today bioinformatics leader ... that uniquely combines lab testing insights and hc1’s exclusive Local Risk Index in ... and safety of employees returning to the workplace. , “Some of the best ...
(Date:5/25/2020)... OXFORD, United Kingdom (PRWEB) , ... May 22, 2020 , ... ... test (assay) for the detection of SARS-CoV-2, the virus that causes COVID-19. ... cater to on-demand analysis of smaller sample numbers, to very large numbers of samples. ...
Breaking Biology News(10 mins):
(Date:6/11/2020)... (PRWEB) , ... June 08, 2020 , ... ... universal vaccine platform delivered through the use of proprietary clean viral vectors, recently ... in the United States. Greffex’s platform is the world’s most successful gene ...
(Date:6/3/2020)... ... 03, 2020 , ... Thought Technology Ltd. is offering a ... installment, Dr. Inna Khazan will discuss the benefits of using mindfulness techniques with ... the feelings, thoughts, and emotions they are having in the present moment and ...
(Date:5/28/2020)... ... 28, 2020 , ... Genedata, the leading provider of enterprise ... ® 17.0, the latest version of its enterprise software for the automated analysis, ... will host a webinar on June 10, 2020, detailing and demonstrating the features ...
(Date:5/21/2020)... ... May 19, 2020 , ... Experienced periodontist in Eden Prairie, MN, Dr. Andres ... grafting through PIEZOSURGERY® technology. PIEZOSURGERY uses ultrasonic vibrations to gently cut bone ... patient for dental implants, especially when the implants need to be placed in a ...
Breaking Biology Technology:
Cached News: