HOME >> BIOLOGY >> NEWS
Study may help clarify how cells grow

CHAPEL HILL - A study led by a University of North Carolina scientist sheds new light on the process of cell growth regulation. The study, which focuses on the complex network of biochemical signals between proteins and enzymes within cells, helps clarify how those signals initiate or limit cell growth.

Although still too basic for clinical use, the findings suggest the possibility of new drugs that would target specific growth-inducing molecules within cancer cells.

A report of the study appears in the January 20 issue of the science journal Nature.

According to Lee Graves, Ph.D., assistant professor of pharmacology at UNC School of Medicine in Chapel Hill and the study's principal investigator, the enzyme MAP kinase (MAPK) is a key component of a signaling pathway initiated by growth factors.

"This is just one of many signaling pathways but we know it's essential for growth," he said. "So the key question has been, what are the specific targets of MAP kinase; that is, what are the important things it does, and how does it regulate cell growth?"

In their search for the answer, Graves and his study collaborators at UNC Lineberger Cancer Center and Wayne State University in Detroit, focused on an enzyme called carbamoyl phosphate synthetase, or CPS II. Deep within the cell's molecular machinery, this enzyme determines the rate of pyrimidine nucleotide biosynthesis, without which cell growth is impossible. Nucleotides are the building blocks of RNA and DNA synthesis. Consequently, blocking the synthesis of these molecules has been the strategy of numerous anti-cancer therapies. Normally, as cellular levels of pyrimidine nucleotides build up, CPS II is turned of by a process of 'feedback' inhibition, Graves explains. "What we think happens is that in response to a growth signal, MAP kinase attaches a phosphorous molecule to CPS II, thus preventing feedback inhibition and allowing cells to make more nucleotides."

The UNC pharmacologist point
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
19-Jan-2000


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... 28, 2018 , ... Johanna Dwyer, founder and Chief Executive ... excellence in the field of intellectual property, and named Daniela Sanchez as the ... Award aims to encourage and support women in their pursuit of careers in ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... essential tool in clinical diagnostic laboratories. However, this technology introduces many well-described ... Hospital London, which leads the South London NHS Genomic Medicine Centre. The ...
(Date:8/23/2018)... ... August 22, 2018 , ... ... LimitLIS® 4.0, the latest version of its rapidly growing cloud-based laboratory information system. ... Edition, as well as the company’s triple digit growth throughout 2018, the RURO ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... September 06, 2018 , ... Akadeum Life Sciences today announced it has ... an executive and leader of numerous biotech companies. , He most recently served ... acquired by Thompson Street Capital in St. Louis, MO. Prior to ISTO, he ...
(Date:8/29/2018)... ... August 28, 2018 , ... Nanovis , an ... successful completion of a $5.5 million funding round managed by Commenda Securities. Key ... Capital, and Ellipsis Ventures. , “Our investment in Nanovis is consistent with our ...
(Date:8/29/2018)... ... ... LabRoots , the leading provider of interactive virtual events for tech ... of a new gamification feature, allowing users to earn points by participating in the ... shirts. , Throughout each month, LabRoots users will earn points by building their profile, ...
(Date:8/23/2018)... ... August 22, 2018 , ... Crucial Data Solutions, Inc. ... it the first fully-featured app for electronic data capture (EDC) and electronic participant ... constitute 99 percent of the market share for mobile devices worldwide; in turn, ...
Breaking Biology Technology:
Cached News: