HOME >> BIOLOGY >> NEWS
Study of insecticide neurotoxicity yields clues to onset of Parkinson's Disease

BLACKSBURG, Va., March 24, 2003 -- A grant from the U.S. Army has led Virginia Tech researchers to discover that exposure to some insecticides may cause a cascade of chemical events in the brain that could lead to Parkinson's Disease.

Jeffrey R. Bloomquist, a neurotoxicologist and associate professor in the university's Department of Entomology, will describe his findings as part of the International Award for Research in Agrochemicals, a symposium honoring Robert M. Hollingworth, at the annual meeting of the American Chemical Society in New Orleans this week.

"We found low-level exposures set in motion a process with an early onset that develops slowly and is persistent," Bloomquist said. "More surprising is that high-level exposures resulted in few immediate effects that we could observe, but in the longer term there was a delayed effect."

The Virginia Tech researchers studied the levels of dopamine, dopamine transporter protein expression, and the levels of a synaptic protein (alpha-synuclein) in mice exposed to various doses of the insecticide permethrin. The increase in dopamine uptake indicated the mouse's system was reacting to a neurochemical insult caused by the presence of the insecticide. The slow response to high levels of exposure to pesticides is caused, Bloomquist thinks, by the system being overloaded and only after a period of a few weeks is it capable of responding to the insult in the same way as low doses.

In some individuals, dopamine-producing neurons may be challenged by genetic factors or by previous exposure to other neurotoxins. For individuals with a genetic predisposition, exposure to permethrin may trigger chemical events in the brain that result in an increased risk for damage to the area of the brain that is selectively damaged in Parkinson's disease.

The loss of motor skills, resulting in symptoms such as muscle rigidity, shuffling gait, and a rhythmic tremor, has been linked to the loss of dopa
'"/>

Contact: Stewart MacInnis
macinnis@vt.edu
540-231-5863
Virginia Tech
24-Mar-2003


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/3/2020)... ... September 03, 2020 , ... ... announced that an extensive third-party assessment of the company’s security practices has been ... against federal security regulations. The comprehensive evaluation reviewed Litmus’ processes and systems, assessing ...
(Date:8/26/2020)... ... August 25, 2020 , ... ... targeting mitochondria, in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in ... 3 VISTA-2 study of SkQ1 ophthalmic solution in patients with moderate to ...
(Date:8/26/2020)... (PRWEB) , ... August 25, 2020 , ... Modality ... made Inc. magazine’s 2020 annual Inc. 5000 list. The list is the most prestigious ... in 2019 as well, and for this year’s list, reported three-year revenue growth of ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... R3 Stem Cell International is now offering patients the ... stem cells total, patients may choose which extremities they would like treated. , Several ... Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a lab ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/22/2020)... ... 22, 2020 , ... Join experts from Reed Tech , Gary Saner, ... a one hour live webinar on Thursday, August 13, 2020 at 11am ... and medical devices. Specifically, for medical devices, the NMPA has departments dealing with medical ...
(Date:7/18/2020)... ... 2020 , ... dicentra , a leading Contract Research ... is pleased to announce that Charles Galea has joined its clinical trials division ... an accomplished and results-driven sales executive with over 10 years of expertise in ...
Breaking Biology Technology:
Cached News: