HOME >> BIOLOGY >> NEWS
Study of proteins offers insights into organization of biological networks

BOSTONResearch into the many-sided interactions of proteins in yeast cells is revealing that such networks may have something in common with other kinds of systems, from the World Wide Web to the country's electric-power grid.

Dana-Farber Cancer Institute investigators report that "hub" proteins highly connected proteins that bind to many other proteins in the cell can be divided into two general groups: "party" hubs, which interact with most of their partner proteins all at once, and "date" hubs, which bind to their partners at different times or locations. The study will be published online by Nature as an Advanced Online Publication on June 9 and later in the print edition.

"Our discovery answers a key question about how yeast cells organize their genetic and protein activity," says Dana-Farber's Marc Vidal, Ph.D, who led the study with colleague Jing-Dong Han, Ph.D. "This might turn out to be critical knowledge for the development of drugs for cancer and other diseases."

The new study is based on a map of the interactions among proteins the so-called "interactome" in yeast cells. Resembling a ball exploding into thousands of colored particles, the map gives a composite view of interactions that can take place among the proteins, but it doesn't indicate how frequently protein partners interact, nor which partners are in action at the same time. "We need a way of analyzing proteins' activity as a dynamic process," Vidal says.

Vidal and his colleagues focused on hub proteins, the social butterflies of the molecular world, which have large numbers of partner proteins. Researchers theorize that abnormal versions of hub proteins are especially influential in the development of cancer and other genetic diseases. Physicist Albert-Laszlo Barabasi of the University of Notre Dame, for example, has used computer modeling to discover that removing hubs from a network is more likely to result in
'"/>

Contact: Janet Haley
janet_haley@dfci.harvard.edu
617-623-5665
Dana-Farber Cancer Institute
9-Jun-2004


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... 03, 2020 , ... Accumen Inc. is helping healthcare get ... Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has ... than 10 years. Early in the COVID-19 crisis, we identified supply chain gaps ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical (ABM), a ... awards for not only the products and treatments developed, but also the dedicated ... RF. All the brands built by ABM have received several honors already for ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... ... industries, announces it has closed on the purchase of greenfield for a new, ... TX and includes over 21 acres in the initial acquisition, with an option ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. ... can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI ... two switches in a push-pull configuration; yielding fast fall time for a capacitive ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
Breaking Biology Technology:
Cached News: