HOME >> BIOLOGY >> NEWS
Study pinpoints regulator of imprinted gene expression

(Embargoed) CHAPEL HILL -- New research at the University of North Carolina at Chapel Hill offers an important contribution to a new wave of thinking in genetics: the idea that not all human disease states are due to alterations in DNA sequence.

A growing body of research on these "epigenetic" changes are leading geneticists to rethink the conventional view that all human disease is fundamentally tied to DNA sequence variation (changes in the actual sequence of the DNA nucleic acid code of A's, C's, G's and T's within any given gene).

The DNA within human cells contains the information for roughly 35,000 different proteins that carry out the body's functions. But not all of these genes are active all of the time. Like switches, epigenetic modifications to proteins surrounding the DNA regulate a given gene's activity, such that only those that are required in a particular cell are active (switched on). These changes constitute a "memory" of gene activity that can be passed on each time a cell divides.

If these epigenetic modifications do not occur properly, the result can cause some genes to become switched on or off incorrectly, thereby having profound biological consequences. Incorrect epigenetic modifications have been implicated in many human disorders including several types of cancer, birth defects and mental retardation.

"These expression changes are heritable and are not related to sequence changes in the gene that is directly affected", said Dr. Terry Magnuson, Kenan professor of genetics and director of the Carolina Center for Genome Sciences. "Sequencing the human genome will not necessarily lead one to discover why these genes are expressed abnormally."

For example, there is a recent awareness among scientists of a new type of health threat posed by environmental chemicals that can disrupt endocrine signals during critical periods of development through epigenetic alterations. Additionally, researchers studying
'"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
9-Mar-2003


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/26/2016)... and LONDON , April ... part of EdgeVerve Systems, a product subsidiary of ... today announced a partnership to integrate the Onegini ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... their customers enhanced security to access and transact ...
(Date:4/15/2016)... April 15, 2016  A new partnership announced ... accurate underwriting decisions in a fraction of the ... priced and high-value life insurance policies to consumers ... With Force Diagnostics, rapid testing (A1C, Cotinine ... readings (blood pressure, weight, pulse, BMI, and activity ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics ... of the National Coordinator for Health IT (ONC) outlining a measurement approach to ... were available when and where it was needed. The organization of health informatics ...
(Date:5/24/2016)... Worcester, Mass. (PRWEB) , ... May 24, 2016 ... ... including heart attacks, diabetes, and traumatic injuries, will be accelerated by research at ... skin cells into engines of wound healing and tissue regeneration. , The novel ...
(Date:5/23/2016)... ... 2016 , ... PrecisionAg® Media has released its latest White ... paper outlines the key trends that are creating both opportunities and challenges for ... of highs and lows as the precision agriculture market has grown and matured ...
(Date:5/23/2016)... Alto, CA (PRWEB) , ... May 23, 2016 ... ... and public interest organization focused on molecular nanotechnology, announced the winners for the ... of pioneer physicist Richard Feynman, are given in two categories, one for experiment ...
Breaking Biology Technology:
Cached News: