HOME >> BIOLOGY >> NEWS
Study points to possible cause of asthma exacerbations

Researchers know that viral infections can exacerbate asthma and, in turn, make people with the condition more sensitive to environmental exposures such as endotoxin. But how viral infections contribute to this sensitivity in airway cells has not been clear. A recent study led by investigators from the University of Iowa Roy J. and Lucille A. Carver College of Medicine and the Veterans Affairs Medical Center (VAMC) in Iowa City shows, for the first time, that viral infections may increase environmental sensitivity in lung epithelial (surface) cells by changing expression of receptors on those cells.

Using cell models, the team specifically showed that respiratory syncytial virus (RSV) infection increases the number of a type of receptor called Toll-4 on the airway cells. This Toll-4 receptor can provide a foothold for inhaled endotoxin, a naturally occurring environmental contaminant that comes from bacteria and is found in household dust, grain dust and objects such as pillows. The presence of receptors for endotoxin would lead to interaction between the epithelial cell and the endotoxin and potentially cause inflammation. The study appeared in the December 26, 2003, issue of the Journal of Biological Chemistry.

"The big picture here is that viral infections may upregulate, or increase, one or more receptors on the airway cells and make them more sensitive to environmental exposures. This could explain the viral-induced asthma exacerbations seen in people with asthma," said Martha Monick, senior research assistant in the Division of Pulmonary, Critical Care and Occupational Medicine in the UI Department of Internal Medicine and the study's co-lead author.

Monick said the inspiration for the study came when the team put endotoxin on normal airway epithelial cells and noticed there was no inflammatory response.

"This puzzled us, so we started thinking about receptors on lung cells," Monick said. "When we looked in normal lung cells for
'"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
24-Mar-2004


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 06, 2018 , ... Sensors Midwest (#SensorsMW18), ... Sensors Expo & Conference , announces their partnership with Fraunhofer USA Center ... IoT Enabled Industrial IoT Certification Program. Taking place on October 17, 2018 at ...
(Date:9/1/2018)... ... 31, 2018 , ... Right this minute, Frenchman Ben Lecomte is hard at work on his ... he’s taken on a new challenge: going from Tokyo to San Francisco, churning his limbs ... on the support boat. As the first expedition of its kind, The Swim is far ...
(Date:8/31/2018)... ... August 30, 2018 , ... CallTower is pleased to ... than 20-years of telecommunications experience and over ten years in executive leadership. Prior to ... by CallTower in early 2018. , In this new role, Jason ...
Breaking Biology News(10 mins):
(Date:8/21/2018)... ... ... The Connecticut Technology Council (CTC) and Marcum LLP today announce the 2018 ... Connecticut. This year’s group of top-ranked companies will be honored at the new ConnectiTECH ... in Hartford. A complete list of the Marcum Tech Top 40 is included below. ...
(Date:8/17/2018)... ... August 16, 2018 , ... KCAS Bioanalytical ... announce the expansion of their team. Dr. Dawn Dufield, Ph.D., joins KCAS as ... large molecule LC-MS/MS group that will specialize in developing quantitative LC-MS/MS assays for ...
(Date:8/17/2018)... Columbia (PRWEB) , ... August 17, 2018 , ... ... International Society for Biological and Environmental Repositories (ISBER) is pleased to announce the ... , The Fourth Edition publication, originally released in January 2018, is a practice-changing ...
(Date:8/14/2018)... ... August 14, 2018 , ... Buprenorphine ... use disorder. BUP is often prescribed as a sublingual co-formulation with the opioid ... this webinar, participants will learn from a review of the pharmacokinetics of BUP, ...
Breaking Biology Technology:
Cached News: