HOME >> BIOLOGY >> NEWS
Study points to possible cause of asthma exacerbations

Researchers know that viral infections can exacerbate asthma and, in turn, make people with the condition more sensitive to environmental exposures such as endotoxin. But how viral infections contribute to this sensitivity in airway cells has not been clear. A recent study led by investigators from the University of Iowa Roy J. and Lucille A. Carver College of Medicine and the Veterans Affairs Medical Center (VAMC) in Iowa City shows, for the first time, that viral infections may increase environmental sensitivity in lung epithelial (surface) cells by changing expression of receptors on those cells.

Using cell models, the team specifically showed that respiratory syncytial virus (RSV) infection increases the number of a type of receptor called Toll-4 on the airway cells. This Toll-4 receptor can provide a foothold for inhaled endotoxin, a naturally occurring environmental contaminant that comes from bacteria and is found in household dust, grain dust and objects such as pillows. The presence of receptors for endotoxin would lead to interaction between the epithelial cell and the endotoxin and potentially cause inflammation. The study appeared in the December 26, 2003, issue of the Journal of Biological Chemistry.

"The big picture here is that viral infections may upregulate, or increase, one or more receptors on the airway cells and make them more sensitive to environmental exposures. This could explain the viral-induced asthma exacerbations seen in people with asthma," said Martha Monick, senior research assistant in the Division of Pulmonary, Critical Care and Occupational Medicine in the UI Department of Internal Medicine and the study's co-lead author.

Monick said the inspiration for the study came when the team put endotoxin on normal airway epithelial cells and noticed there was no inflammatory response.

"This puzzled us, so we started thinking about receptors on lung cells," Monick said. "When we looked in normal lung cells for
'"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
24-Mar-2004


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... TORONTO (PRWEB) , ... August 13, 2019 , ... ... Cancer Medicine Team, Division of Molecular Pathology, Institute of Cancer Research (ICR) in ... (5pm BST/UK) to learn about the process of biomarker and companion diagnostic development ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... a computational modeling system that could have far-reaching implications for personalized medicine, especially ... squares regression (PLSR), is able to predict which stem cell donors and manipulation ...
(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... ... technology, is pleased to announce its attendance at the Microscopy & Microanalysis 2019 ... Portland, Oregon at the Oregon Convention Center. , The Microscopy & Microanalysis Meeting, ...
Breaking Biology News(10 mins):
(Date:7/11/2019)... VEGAS (PRWEB) , ... July 11, 2019 , ... At ... R3 provided complimentary regenerative therapies to eight military Veterans under the R3 Heroes Program. ... being complimentary. , The R3 Heroes Program allow anyone to nominate a military Veteran, ...
(Date:7/9/2019)... ... July 08, 2019 , ... ... SmartLight Indicator was recognized as the 2019 Innovative Product of the Year which ... prestigious awards were during Sensors Expo & Conference 2019, held this ...
(Date:6/26/2019)... ... ... Alice Branton today released research results from preclinical trials on the beneficial ... prove to be beneficial for treating Hypomagnesemia. , The preclinical trial shows:, ... , Over 142% increase in particle size , Over 3% ...
(Date:6/18/2019)... POWAY, Calif. (PRWEB) , ... June 18, 2019 , ... ... submitted an Investigational New Drug (IND) application to the FDA for use of a ... stem cells as a treatment of osteoarthritis in the knee. This IND is ...
Breaking Biology Technology:
Cached News: