HOME >> BIOLOGY >> NEWS
Study points to possible cause of asthma exacerbations

the receptors for endotoxin, we found there were very low levels and they were inside the cell, not on the surface."

With that observation, the investigators wanted to see what happened to endotoxin receptors when lung cell models were infected by a virus. The team used RSV, which normally does not cause serious illness in healthy people but has epidemiological links to asthma and asthma exacerbations. They found that this virus increased both the amount and the surface expression of the receptors for endotoxin on cells lining the airway. Next, they exposed RSV-infected lung cells to endotoxin and saw the increased inflammatory response.

"The increased expression of the Toll-4 receptor after the viral infection markedly increased the sensitivity of the epithelial cells to endotoxin exposure," said Gary Hunninghake, M.D., a study author and the Sterba Professor of Internal Medicine with the UI Carver College of Medicine and a researcher and staff physician with the Iowa City VAMC.

The increased endotoxin response results in proteins that cause inflammation, constricting the airways of people with asthma. It is likely that viruses also increase the response of the airways to other environmental exposures. This increased non-specific response of asthmatic airways to environmental exposures is a typical feature of asthma, Hunninghake said.

"The next phase of these studies is to determine if viruses cause the same effect in individuals with asthma," said Hunninghake, who directs the UI Division of Pulmonary, Critical Care and Occupational Medicine and also directs the Graduate Program in Translational Biomedicine.

The team will study if the change they saw in receptor expression after RSV infection will occur in animal models of asthma and in cells taken from nasal washes of patients with asthma.

In addition to Monick and Hunninghake, the team included co-lead author Timur Yarovinsky, Ph.D., UI assistant research scientis
'"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-335-6660
University of Iowa
24-Mar-2004


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... May 20, 2019 , ... Dr. David Greene , ... The documentary, Stem Cell Therapy: Biotechnology to the Rescue, was produced by Award Winning ... Greene was interviewed in regards to the safety of the procedures along with the ...
(Date:5/21/2019)... Pa. (PRWEB) , ... May 20, 2019 , ... ... for the health care field, today announced a 96.15% pass rate for first-time ... of 2019. This surpasses the national average of 76.43% by nearly 20 points. ...
(Date:5/16/2019)... (PRWEB) , ... May 16, 2019 , ... In a ... and Technology in Rockville, Maryland, March 18-19 of this year, Asymmetrex founder ... the feasibility of standards for counting therapeutic adult tissue stem cells. Many of ...
Breaking Biology News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... Taking a ... includes a chemical engineer at Worcester Polytechnic Institute (WPI) has developed a novel ... possible to manufacture isobutanol and other biofuels more economically. , Isobutanol, like ethanol, ...
(Date:4/16/2019)... ANTONIO (PRWEB) , ... April 16, 2019 , ... ... human identification systems, applications, and technology, today announced that Bank South Pacific (BSP), ... a competitive RFP process. The bank awarded Fulcrum a contract to deliver a ...
(Date:4/12/2019)... (PRWEB) , ... April 12, 2019 , ... ... recent developments in neurotechnology and will educate about innovative tools and devices being ... your local listings for more information. , This segment of Advancements will focus ...
(Date:4/10/2019)... ... ... After more than three months of renovation, Lajollacooks4u is set to reveal its ... modern lighting and fixtures, and will provide additional workspace for the many guests who ... the demand for our team-building events and cooking classes over the last eleven years,” ...
Breaking Biology Technology:
Cached News: