HOME >> BIOLOGY >> NEWS
Study provides new details of 'the birth of a virus'

BOSTON - With sinister efficiency, retroviruses such as HIV use only a small portion of their genetic programming to steal away from the cell where they were born and infect other cells. A study published this week by scientists at Dana-Farber Cancer Institute provides new details of how retroviruses make their escape and cloak themselves in the cell's membrane to avoid attack from the body's immune system.

The study, published in the November 21 issue of the Proceedings of the National Academy of Sciences, is one of three in the journal to focus on the mechanics of viral departure from cells - research that may one day lead to new techniques for arresting the process and preventing the spread of viral infection within the body.

"The last stages of the formation of viruses within cells and the process by which viruses leave cells are among the least understood aspects of the viral life cycle," says senior author Heinrich Gttlinger, M.D., of Dana-Farber and Harvard Medical School. "Our research sheds light on previously unknown aspects of this process and on the mechanisms that cause a virus to assemble in the first place."

The Dana-Farber study spotlights the function of ubiquitins, which help viruses break free from the cells where they were born, and on a viral segment known as the "late domain," which is in a protein called Gag. The domain, as its name suggests, comes into play late in the process by which viruses are assembled inside cells, just before they leave to infect other cells.

The process works like this: After infecting a cell, a virus takes over a cell's reproductive machinery to produce thousands of copies of itself. The not-yet-fully-assembled viruses - really just packets of RNA at this point - congregate inside the cell membrane like protesters pressing against a police barricade. The cell membrane begins to bulge and eventually forms a "bubble" that seals the viral RNA off from the rest of th
'"/>

Contact: Todd Ringler
todd_ringler@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
20-Nov-2000


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/16/2017)... SAN FRANCISCO , Feb. 16, 2017 /PRNewswire/ ... research, today announced that it has received Laboratory ... The CAP Accreditation is presented to laboratories that ... and who demonstrate scientifically rigorous processes. ... of excellence in laboratory practices. We,re honored to ...
(Date:2/10/2017)... Research and Markets has announced the addition of ... Commercial Aspects" to their offering. ... Biomarkers play an important ... selection of treatment as well for monitoring the results. There ... modern medicine. Biochip/microarray technologies and next generation sequencing are also ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion in ... a compound annual growth rate (CAGR) of 24.0% through 2021. ... for synthetic biology. - Analyses of global market trends, with ... annual growth rates (CAGRs) through 2021. - Coverage of core ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... , ... February 22, 2017 , ... Park Systems ... free AFM Luncheon for all SPIE attendees and Park customers on ... one block from the San Jose Convention Center. The luncheon will feature a ...
(Date:2/22/2017)... (PRWEB) , ... February 22, 2017 , ... ... discovery and development of precision treatments for neurodegenerative diseases, today announced it has ... the ProMIS approach.” This is one of a series of commentaries from ProMIS’s ...
(Date:2/22/2017)... -- Origin (Origin Agritech, LLC, a subsidiary of Origin Agritech Ltd.) ... Arcadia (Arcadia Biosciences, Inc., NASDAQ: RKDA), a ... traits and nutritional products, today announced their collaboration to achieve the ... China to the United States ... ...
(Date:2/22/2017)... SAN DIEGO , Feb. 22, 2017 ... announced today expansion of its translational research program ... through establishment of laboratory facilities in San Diego.  ... San Diego BioLabs facility, a biotechnology incubator sponsored ... Sanofi. In November 2016, the Company ...
Breaking Biology Technology:
Cached News: