HOME >> BIOLOGY >> NEWS
Study provides new details of 'the birth of a virus'

e cell (see accompanying illustration). Thousands of newborn viruses now cling to the outside of the membrane, waiting for one final step to cut them loose and send them on their way to other cells.

Ten years ago, Gttlinger and his colleagues at Dana-Farber discovered that a strain of HIV that lacks the late domain was unable to break free of the membrane - remaining attached and posing no threat to the rest of the body. The new study fills in some of the gaps in scientists' understanding of how the late domain functions and how it serves as a passport through the cell's skin.

Small as the late domain is within Gag, the domain's essential core - the part that enables it to function - often consists of only a handful of molecules, primarily amino acids known as prolines. Researchers have found that all retroviruses, not just HIV, have late domains, as do a variety of other viruses.

"These findings suggest that many viruses use the same or similar mechanisms to cut themselves loose from the cell membrane," Gttlinger says. "The discovery of the proline-rich sections of the late domain enabled us to focus on precisely these areas in studying how the domain functions." The researchers hypothesized that the late domain serves as a target for cell proteins that help the virus break free from the cell membrane. Their research shows this to be precisely the case.

The possibility of interrupting the budding process marks the significance of this recently published research. Working independently, scientists at Dana-Farber Cancer Institute, Penn State's College of Medicine and The National Institute of Allergies and Infectious Diseases (NIAID) of the National Institutes of Health, published complementary papers on the role of the cellular ubiquitination machinery in late steps of retrovirus budding.

The data show the functional connection between ubiquitin and Gag (Penn State), the recruitment of ubiquitin ligase, which encourages the
'"/>

Contact: Todd Ringler
todd_ringler@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
20-Nov-2000


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... & Trends - Industry Forecast to 2025" report to their ... The ... CAGR of around 8.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/20/2017)... 20, 2017 PMD Healthcare announces the release ... Wellness Management System (WMS), a remote, real-time lung health ... PMD Healthcare is a Medical Device, Digital Health, and ... to creating innovative solutions that empower people to improve ... focus, PMD developed the first ever personal spirometer, Spiro ...
(Date:3/7/2017)... 2017 Brandwatch , the leading social intelligence company, ... Trust to uncover insights to support its reporting, help direct ... The UK,s leading youth charity will be using Brandwatch Analytics social ... a better understanding of the topics and issues that are a ... ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... ... dedicated to finding cures for inflammatory bowel diseases (IBD), and ReachMD , ... deliver exclusive content to ReachMD learners. , The partnership, which launched in ...
(Date:3/29/2017)... March 29, 2017  Vermillion, Inc. (NASDAQ: VRML), ... reported on its results for the fourth quarter ... "2016 marked a pivotal year for us ... inclusion, international distribution agreements, major reimbursement progress with ... payer agreements. In addition we cleared our 2 ...
(Date:3/29/2017)... March 29, 2017 "Surging application of gesture ... the government are expected to drive the growth of ... gesture recognition market is expected to be worth USD ... 29.63% between 2017 and 2022. The touchless sensing market ... 2022, growing at a CAGR of 17.44% between 2017 ...
(Date:3/29/2017)... SHANGHAI , March 29, 2017 ... technology platform company dedicated to biologics and a ... received the 2017 Asia-Pacific Best Bioprocessing Excellence Award ... Asia-Pacific Bioprocessing Excellence Awards aims to recognize outstanding ... of tomorrow. Featuring top bioprocessing and biomanufacturing experts ...
Breaking Biology Technology:
Cached News: