HOME >> BIOLOGY >> NEWS
Study provides new details of 'the birth of a virus'

e cell (see accompanying illustration). Thousands of newborn viruses now cling to the outside of the membrane, waiting for one final step to cut them loose and send them on their way to other cells.

Ten years ago, Gttlinger and his colleagues at Dana-Farber discovered that a strain of HIV that lacks the late domain was unable to break free of the membrane - remaining attached and posing no threat to the rest of the body. The new study fills in some of the gaps in scientists' understanding of how the late domain functions and how it serves as a passport through the cell's skin.

Small as the late domain is within Gag, the domain's essential core - the part that enables it to function - often consists of only a handful of molecules, primarily amino acids known as prolines. Researchers have found that all retroviruses, not just HIV, have late domains, as do a variety of other viruses.

"These findings suggest that many viruses use the same or similar mechanisms to cut themselves loose from the cell membrane," Gttlinger says. "The discovery of the proline-rich sections of the late domain enabled us to focus on precisely these areas in studying how the domain functions." The researchers hypothesized that the late domain serves as a target for cell proteins that help the virus break free from the cell membrane. Their research shows this to be precisely the case.

The possibility of interrupting the budding process marks the significance of this recently published research. Working independently, scientists at Dana-Farber Cancer Institute, Penn State's College of Medicine and The National Institute of Allergies and Infectious Diseases (NIAID) of the National Institutes of Health, published complementary papers on the role of the cellular ubiquitination machinery in late steps of retrovirus budding.

The data show the functional connection between ubiquitin and Gag (Penn State), the recruitment of ubiquitin ligase, which encourages the
'"/>

Contact: Todd Ringler
todd_ringler@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
20-Nov-2000


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available ... bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, supplementing ...
(Date:10/6/2017)... , ... October 06, 2017 , ... ... within the healthcare and technology sector at their fourth annual Conference where founders, ... 30 inspiring speakers and the ELEVATE pitch competition showcasing early stage digital health ...
Breaking Biology Technology:
Cached News: