HOME >> BIOLOGY >> NEWS
Study reveals enzyme that behaves like a 'quantum inchworm'

Little is known about the actions of the tiny, critically important machines that maintain DNA, the chemical code coiled inside all living cells. Now UC Davis researchers have peered under the hood of one such machine to reveal new details about the workings of these essential housekeepers.

RecBC is an enzyme that works inside the E. coli bacterium. This nanomachine, one one-billionth of a meter in size, is a molecular motor. It moves along DNA, separating the two sides of the ladder-shaped DNA so that its rungs can be repaired, their code can be read or they can be paired with another DNA partner.

Most DNA investigators expected that RecBC would move along one to five rungs, or nucleotides, at a time -- a respectable step size for enzymes. But in Thursday's issue of the journal Nature, microbiologists Stephen Kowalczykowski and Piero Bianco report that RecBC has the longest stride yet seen. It is an enzymatic Paul Bunyan, striding ahead 23 rungs every advance.

That kind of workout burns a lot of fuel, and the new finding will require researchers to think differently about how such enzymes use cellular energy sources.

The researchers also found that RecBC has a unique gait. Its front end completes its 23-rung advance, anchors itself to the DNA, and then pulls its back end forward, separating the DNA behind it in a plowlike fashion. Because of this novel mechanism, the researchers dubbed RecBC the "quantum inchworm."

"Overall, understanding this protein will further our understanding of how to maintain chromosomes and to correct genetic defects," said Kowalczykowski. On a smaller scale, literally, the new findings may help engineers who are trying to build nanomachines for jobs such as delivering new genes to DNA or drugs to specific genetic targets in cancer cells, he said.


'"/>

Contact: Stephen Kowalczykowski
sckowalczykowski@ucdavis.edu
530-752-5938
University of California - Davis
16-May-2000


Page: 1

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/11/2018)... ... October 11, 2018 , ... ODSC Europe 2018 - one of ... attendance at the event from September 19-22. , As Europe’s largest applied data ... 10 tracks and 4 days. Attendees were given key insights and hands-on training ...
(Date:10/11/2018)... ... October 11, 2018 , ... Better lives through a healthy ... Innovation in Manufacturing Biopharmaceuticals (NIIMBL). The Institute, a public-private partnership launched in March ... workforce development in the United States. Biopharmaceuticals are important because they treat and ...
(Date:10/5/2018)... ... October 04, 2018 , ... CallTower Inc., ... was present at Microsoft Ignite 2018, in Orlando, Florida, when Microsoft made a ... a statement about the new direction of Skype for Business Online, outlining the ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... ... September 28, 2018 , ... GlycoMark®, Inc. has announced ... the GlycoMark test, the only FDA-cleared blood test specific to detecting recent hyperglycemia ... and offer the GlycoMark test to its network of physicians through its sales ...
(Date:9/27/2018)... ... September 26, 2018 , ... NDA ... Cimler, a senior quality, regulatory, and in vitro diagnostic device expert with more ... industry has joined the firm as an Expert Consultant. Her experience includes leadership ...
(Date:9/27/2018)... ... September 26, 2018 , ... Medable ... that aims to build the first human digitome, a digital representation of human ... through a seamless integration of all data sources. Dr. Michelle Longmire, Co-Founder and ...
(Date:9/27/2018)... ... September 27, 2018 , ... This past weekend ... SureAdhere Mobile Technology, Inc. announced they will formally merge companies and integrate their ... tuberculosis (TB) and other diseases. These two social enterprise corporations, both of which ...
Breaking Biology Technology:
Cached News: