HOME >> BIOLOGY >> NEWS
Study reveals new information on how viruses enter cells

WEST LAFAYETTE, Ind. A detailed look at a syringe-like structure designed to inject viral DNA into a host cell reveals a unique and complex entry scheme for viruses.

The study may provide clues to how similar viruses infect cells and suggest ways for developing a new class of antibiotics and other drugs to prevent illnesses caused by viral pathogens.

Scientists at Purdue University have solved the three-dimensional structure of the bacteriophage T4 virus, a virus that resembles a lunar lander in both its looks and intricate workings.

The study, published in the Jan. 31 issue of the journal Nature, reveals for the first time how the virus binds to the surface of the host, punctures the cell wall with a syringe-like tube and injects its own genetic blueprint into the cell. This genetic information then sets the cell's machinery to work creating replicas of the virus.

"Though the T4 virus has been studied extensively in the past, this study provides the first detailed information on the virus structure and how it works," says Michael Rossmann, Hanley Distinguished Professor of Biological Sciences at Purdue who directed the study.

Bacteriophage T4 is a virus that infects only bacteria, in this case E. coli, a bacteria used extensively in molecular biology research. The study of bacterial viruses such as T4 is useful in understanding many basic functions in biology, Rossmann says.

"This particular study tells us a great deal about how a virus infects a cell," he says. "These processes tend to be quite general, so mechanisms used by one virus often are similar to mechanisms used by other viruses, including those that infect humans."

Bacteriophages may play a future role in controlling disease-causing bacteria, says Kamal Shukla, the National Science Foundation project officer for this research.

"Knowing the exact mechanism of T4 bacteriophage infectivity is a significant break
'"/>

Contact: Susan Gaidos
sgaidos@purdue.edu
765-494-2081
Purdue University
30-Jan-2002


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... prestigious international IAIR Award for the most innovative high security ePassport and ... ... Maldives Immigration Controller General, Mr. Mohamed ... the right) have received the IAIR award for the "Most innovative high ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... Ca (PRWEB) , ... May 25, 2017 , ... ... of Terumo BCT case studies, describing how process development and economic ... new results of T-cell expansion using a hollow-fiber bioreactor system, along with techniques ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... as treasurer for the Mid-Atlantic chapter of the Healthcare Businesswomen’s Association ... , The HBA Mid-Atlantic chapter board meets in person once each quarter and ...
(Date:5/24/2017)... ... May 23, 2017 , ... Federal funding for basic and applied scientific research ... medical and other vital technologies — deserves continued support, say leaders of SPIE, ... community today in responding to the President’s budget request for Fiscal Year 2018. , ...
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex today ... makes it easy for organizations to send and gather large files and confidential ... or email file size limitations. , Using the same market-tested infrastructure as ...
Breaking Biology Technology:
Cached News: