HOME >> BIOLOGY >> NEWS
Study reveals new information on how viruses enter cells

WEST LAFAYETTE, Ind. A detailed look at a syringe-like structure designed to inject viral DNA into a host cell reveals a unique and complex entry scheme for viruses.

The study may provide clues to how similar viruses infect cells and suggest ways for developing a new class of antibiotics and other drugs to prevent illnesses caused by viral pathogens.

Scientists at Purdue University have solved the three-dimensional structure of the bacteriophage T4 virus, a virus that resembles a lunar lander in both its looks and intricate workings.

The study, published in the Jan. 31 issue of the journal Nature, reveals for the first time how the virus binds to the surface of the host, punctures the cell wall with a syringe-like tube and injects its own genetic blueprint into the cell. This genetic information then sets the cell's machinery to work creating replicas of the virus.

"Though the T4 virus has been studied extensively in the past, this study provides the first detailed information on the virus structure and how it works," says Michael Rossmann, Hanley Distinguished Professor of Biological Sciences at Purdue who directed the study.

Bacteriophage T4 is a virus that infects only bacteria, in this case E. coli, a bacteria used extensively in molecular biology research. The study of bacterial viruses such as T4 is useful in understanding many basic functions in biology, Rossmann says.

"This particular study tells us a great deal about how a virus infects a cell," he says. "These processes tend to be quite general, so mechanisms used by one virus often are similar to mechanisms used by other viruses, including those that infect humans."

Bacteriophages may play a future role in controlling disease-causing bacteria, says Kamal Shukla, the National Science Foundation project officer for this research.

"Knowing the exact mechanism of T4 bacteriophage infectivity is a significant break
'"/>

Contact: Susan Gaidos
sgaidos@purdue.edu
765-494-2081
Purdue University
30-Jan-2002


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... ... a wide range of overlapping clinical features. The advancement of targeted next-generation sequencing ... of NDD research and testing. , However, designing a custom panel for ...
(Date:7/16/2017)... ... 16, 2017 , ... OHAUS Corporation, a leading worldwide manufacturer ... new line of Extreme Environment Shakers today. , Extreme Environment Shakers , OHAUS ... optimal cell growth such as cell cultures, solubility studies and extraction procedures. These ...
(Date:7/14/2017)... Denville, USA/ Martinsried, Germany (PRWEB) , ... July ... ... a newly developed standardized solution for sample preparation of proteins to clean peptides ... the Diagenode Bioruptor® sonication system. , The PreOmics iST Kit is based ...
(Date:7/13/2017)... ... July 13, 2017 , ... Frederick’s first ... experienced robust growth in the past year after an intensive restructuring. Under the ... Acceleration Programs and expanded its board of directors to revitalize the organization. As ...
Breaking Biology Technology:
Cached News: