HOME >> BIOLOGY >> NEWS
Study sheds light on how the sun causes skin cancer

BOSTON Researchers at Dana-Farber Cancer Institute have made a discovery that could help solve a mystery in cancer biology: how a sunburn acquired during a childhood day at the beach can develop into a deadly tumor decades later. The scientists report in the Feb. 4 Proceedings of the National Academy of Sciences that the sun's damaging ultraviolet (UV) rays target a series of biochemical signals inside the young skin cell, impairing the cell's ability to control its proliferation. The paper currently is available on the journal's web site.

Lynda Chin, MD, and her colleagues found that they could increase both the number of tumors and the speed with which they formed by exposing newborn mice with an intact Rb pathway to UV radiation. (A pathway is a chain of biochemical signals that regulates cellular activity.) Those mice in which the Rb pathway was already essentially knocked out were unaffected by the dose of UV radiation. "It looks like the Rb pathway is specifically targeted by ultraviolet radiation," said Chin, the study's senior author. Karupiah Kannan, PhD, and Norman Sharpless, MD, formerly at the DFCI, are first authors on the study.

Melanoma is the deadliest form of skin cancer and, left unchecked, can spread aggressively to other parts of the body. However, if caught early, many melanoma lesions can be effectively treated surgically. The discovery that UV radiation triggers melanoma formation by dismantling a specific pathway inside the skin's pigment-producing cells, or melanocytes, offers the possibility of an efficient means of distinguishing, at an early stage, cancerous moles from non-cancerous ones.

"If you see in a sun-induced lesion that its Rb pathway has been inactivated, then the risk of it becoming a melanoma is much greater than one without such a lesion," said Chin, who is also an assistant professor of dermatology at Harvard Medical School. "You could then use that as a prognostic factor to determine which of these
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
30-Jan-2003


Page: 1 2 3 4

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study sheds light how the sun causes skin cancer

(Date:7/20/2015)... -- Acuity Market Intelligence,s latest research "The Global Biometrics ... Privacy" forecasts that between 2014 and 2020 nearly ... to smart mobile devices by 2.2 billion mobile ... to generate more than $67.9 billion in total ...    "Biometrics is at the center ...
(Date:7/9/2015)... , July 07, 2015 ... announced the addition of the "Biometrics for ... Forecasts 2015-2020" report to their offering. ... major contributor to this growth and the forecast ... billion in revenue for companies involved in delivering ...
(Date:7/8/2015)... NEW YORK , July 8, 2015  BD ... announced BD & Guidepoint Mentor, a new ... to Guidepoint,s expert network services. BD ... technologies to improve healthcare delivery and outcomes and, with ... start-up entrepreneur will be able to directly engage with ...
Breaking Biology News(10 mins):Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
(Date:7/29/2015)... ... 29, 2015 , ... Available in select spas and ... nighttime-specific product that targets fat cells for extreme contouring action. During sleep key ... cells, inhibiting the formation of new fat. Upon waking CHRONODIET breaks down fat ...
(Date:7/29/2015)... ... July 29, 2015 , ... Nearly everyone has heard of the potential ... realize that a rich source of these cells is teeth—baby teeth that come loose ... to be pulled to make room for braces. These potent stem cells exist ...
(Date:7/28/2015)... Nev. , July 28, 2015  PDL BioPharma, ... today announced that the Company will release its second ... 30, 2015, on Wednesday, August 5, 2015, after market ... webcast that day at 4:30 p.m. Eastern Time to ... the call will be available via the webcast link ...
(Date:7/28/2015)... July 21, 2015 ... the addition of the "Analysis of the ... their offering. Globally, flow cytometry remains ... cell proliferation, cancer, and stem cells. But the ... primarily because of demand from underdeveloped nations to ...
Breaking Biology Technology:Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2Analysis of the Global Flow Cytometry Market 2012-2018 with a 2014 Base Year and a 2015-2018 Forecast Period 2
Cached News: