HOME >> BIOLOGY >> NEWS
Study sheds light on how the sun causes skin cancer

BOSTON Researchers at Dana-Farber Cancer Institute have made a discovery that could help solve a mystery in cancer biology: how a sunburn acquired during a childhood day at the beach can develop into a deadly tumor decades later. The scientists report in the Feb. 4 Proceedings of the National Academy of Sciences that the sun's damaging ultraviolet (UV) rays target a series of biochemical signals inside the young skin cell, impairing the cell's ability to control its proliferation. The paper currently is available on the journal's web site.

Lynda Chin, MD, and her colleagues found that they could increase both the number of tumors and the speed with which they formed by exposing newborn mice with an intact Rb pathway to UV radiation. (A pathway is a chain of biochemical signals that regulates cellular activity.) Those mice in which the Rb pathway was already essentially knocked out were unaffected by the dose of UV radiation. "It looks like the Rb pathway is specifically targeted by ultraviolet radiation," said Chin, the study's senior author. Karupiah Kannan, PhD, and Norman Sharpless, MD, formerly at the DFCI, are first authors on the study.

Melanoma is the deadliest form of skin cancer and, left unchecked, can spread aggressively to other parts of the body. However, if caught early, many melanoma lesions can be effectively treated surgically. The discovery that UV radiation triggers melanoma formation by dismantling a specific pathway inside the skin's pigment-producing cells, or melanocytes, offers the possibility of an efficient means of distinguishing, at an early stage, cancerous moles from non-cancerous ones.

"If you see in a sun-induced lesion that its Rb pathway has been inactivated, then the risk of it becoming a melanoma is much greater than one without such a lesion," said Chin, who is also an assistant professor of dermatology at Harvard Medical School. "You could then use that as a prognostic factor to determine which of these
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
30-Jan-2003


Page: 1 2 3 4

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study sheds light how the sun causes skin cancer

(Date:5/10/2015)... , May 11, 2015 Fingerprint Cards ... FPC1025 and FPC1155 from the distributor World Peace Industrial Group ... distributors in Asia . Deliveries are planned ... be used by smartphone manufacturers in China ... the communicated revenue guidance of + 1 000 MSEK for 2015. ...
(Date:5/5/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... commerce market, reminds investors and media that  Mr. David ... CARTES SECURE CONNEXIONS AMERICA 2015, held in Washington ... three-day conference is organized into a series of nine session ... Global Fraud: Where is the Trust in Cyberspace? and ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3
(Date:5/28/2015)... , May 28, 2015  GenVec, Inc. (Nasdaq: ... CEO, Douglas J. Swirsky , will present a ... at 11 a.m. EDT on Thursday, June 4, 2015. ... Mr. Swirsky,s presentation will be available at the following ... available on GenVec,s website.  To access, visit www.genvec.com ...
(Date:5/28/2015)... 2015 The Fertility Centers of New ... Danielle Vitiello has taken on a new and expanded ... will provide guidance, leadership, oversight and quality assurance for ... Vitiello among our team of experienced reproductive endocrinologists,” said ... A. Hill, M.D. “Her expertise and compassionate, individualized care ...
(Date:5/28/2015)... Whitehouse Laboratories is excited to announce that ... with PTI Inspection Systems. Whitehouse Labs and PTI will ... method development and validation programs using the most ... includes a more formal program that facilitates cross training ... enables a more effective team approach, especially as it ...
(Date:5/28/2015)... 2015 American Process Inc. (Atlanta, ... TN) recently signed a joint agreement ... resins using nanocellulose, a rapidly emerging high performance, ... is the limited number of feedstock materials available. ... to printed parts for load bearing applications. ...
Breaking Biology Technology:GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 2American Process Inc. Announces Partnership with Oak Ridge National Laboratory to Make 3D Printing Plastic Resins Stronger and More Sustainable 3
Cached News: