HOME >> BIOLOGY >> NEWS
Study sheds light on how the sun causes skin cancer

BOSTON Researchers at Dana-Farber Cancer Institute have made a discovery that could help solve a mystery in cancer biology: how a sunburn acquired during a childhood day at the beach can develop into a deadly tumor decades later. The scientists report in the Feb. 4 Proceedings of the National Academy of Sciences that the sun's damaging ultraviolet (UV) rays target a series of biochemical signals inside the young skin cell, impairing the cell's ability to control its proliferation. The paper currently is available on the journal's web site.

Lynda Chin, MD, and her colleagues found that they could increase both the number of tumors and the speed with which they formed by exposing newborn mice with an intact Rb pathway to UV radiation. (A pathway is a chain of biochemical signals that regulates cellular activity.) Those mice in which the Rb pathway was already essentially knocked out were unaffected by the dose of UV radiation. "It looks like the Rb pathway is specifically targeted by ultraviolet radiation," said Chin, the study's senior author. Karupiah Kannan, PhD, and Norman Sharpless, MD, formerly at the DFCI, are first authors on the study.

Melanoma is the deadliest form of skin cancer and, left unchecked, can spread aggressively to other parts of the body. However, if caught early, many melanoma lesions can be effectively treated surgically. The discovery that UV radiation triggers melanoma formation by dismantling a specific pathway inside the skin's pigment-producing cells, or melanocytes, offers the possibility of an efficient means of distinguishing, at an early stage, cancerous moles from non-cancerous ones.

"If you see in a sun-induced lesion that its Rb pathway has been inactivated, then the risk of it becoming a melanoma is much greater than one without such a lesion," said Chin, who is also an assistant professor of dermatology at Harvard Medical School. "You could then use that as a prognostic factor to determine which of these
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
30-Jan-2003


Page: 1 2 3 4

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2019)... ... February 26, 2019 , ... ... In her position as Account Manager, Ms. Baptiste demonstrated her ability to advocate ... experience. Ms. Baptiste was responsible for partnering with both the Strategic Development team ...
(Date:2/22/2019)... ... February 21, 2019 , ... Clean label food is ... when creating natural foods and beverages. It is quite common to spot consumers running ... meat products are not immune to this label scrutiny. , More than ever, ...
(Date:2/22/2019)... ... February 21, 2019 , ... The ... executed a research agreement establishing a collaborative program to work toward applications of ... develop new radiopharmaceutical lead candidates and will explore Fuzionaire Dx’s platform as a ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... 14, 2019 , ... Open registration for the Case Management ... of Case Management,” continues as CMSA makes plans to host the annual event ... management industry conference serving the educational and networking needs of case and care ...
(Date:3/14/2019)... (PRWEB) , ... March 13, 2019 , ... ... its 2019 ISPE Europe Biotechnology Conference , taking place in Brussels, Belgium ... biotechnology best practices, technical and operational solutions, and innovative approaches. , “Biopharmaceuticals ...
(Date:3/12/2019)... (PRWEB) , ... March 12, 2019 , ... ... preparation and epigenetics research, has launched its third generation long-fragment DNA shearing innovation, ... generation instrument with a user-friendly interface, automated processing, and the ability to ...
(Date:3/9/2019)... ... March 07, 2019 , ... ACEA Biosciences ... development and commercialization of high performance, cutting-edge cell analysis platforms for life science ... GLP-certified expertise in cardiovascular pharmacology and electrophysiology, are announcing a partnership to provide ...
Breaking Biology Technology:
Cached News: