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Study shows first direct evidence that transplanted muscle cells can take root in damaged hearts

CHICAGO The first direct evidence that muscle cells transplanted from within a heart patient's body could help heal their damaged heart muscle is being reported today by a team from the University of Michigan Health System, Massachusetts General Hospital Hospital and Diacrin, Inc.

The results come from three patients who had cells from their thigh muscles injected into their heart muscle while they awaited a heart transplant, then allowed their old, damaged hearts to be examined for signs of cell growth after they got a new heart.

The detailed examinations, the first of their kind, showed that the injected cells not only survived in their new environment, but began to form muscle fibers. The areas where cells were injected also had an increase in the formation of small blood vessels. None of the patients experienced immune reactions to the cell transplants.

"These results give us the first indication that muscle cell transplants, even from an entirely different kind of muscle, could one day be used to help repair damaged, failing hearts without danger of rejection," says U-M cardiac surgeon Francis Pagani, M.D., Ph.D., who will present the results today at the Scientific Sessions of the American Heart Association. "We have much further to go, but we're very encouraged."

The detailed findings come from one arm of a two-part Phase I study sponsored by Diacrin, designed to see if transplanted skeletal muscle cells might be a feasible option for repairing hearts damaged by heart attack and other diseases.

The study relies on the premise that certain kinds of cells can be expanded in culture and maintain their functional characteristics. Though similar to the concept of "stem cells" that can become any kind of cell in the body, the study uses "satellite cells", which occur naturally in muscle and help repair damage by dividing and moving to injured areas.

The arm of the study conducted at UMHS and Temple University invol
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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
17-Nov-2002


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