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Study suggests ERT stimulates blood flow to key memory centers in brain

ons 24 months later. Utilizing the PET scans and other computer technology, Drs. Maki and Resnick were able to observe differences in brain blood flow over time between the two groups of women as they performed these cognitive tasks.

Overall, the women using ERT scored higher on memory tests, Dr. Maki said. PET scans showed that over time these women also had increased blood flow in some of the same brain regions that form memory circuits and that are prone to preclinical abnormalities in individuals at increased genetic risk for Alzheimer's disease and in individuals who go on to develop dementia. These brain regions include the hippocampus, parahippocampal gyrus, and middle temporal lobe.

"This study adds credence to prior research that implies estrogen may be beneficial to cognitive aging," Dr. Maki said. "It really gives us the first direct insight into how the brain responds to estrogen over time, and how estrogen might protect against normal and abnormal memory changes as we age." This paper appears in the de la Torre Special Issue, Neurobiology of Aging, volume 21, Number 2, pages 373-383.


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Contact: Doug Dollemore
DollemoD@nia.nih.gov
301-496-1752
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26-Jun-2000


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