HOME >> BIOLOGY >> NEWS
Study suggests cell-cycle triggers might be cancer drug targets

BOSTON--In an experiment that appears to refute current theory, Dana-Farber Cancer Institute scientists have found that removing three key proteins believed essential to cell division and growth had little impact on normal tissue development of a mouse embryo. These same proteins, when overly active, have been linked to cancer cell proliferation.

With one significant exception, the absence of proteins called cyclin D1, D2, and D3 seemed to have no deleterious effect on development of the tissues and organs of laboratory mouse embryos. "D-type cyclins" are molecules that sense growth signals from the cell's environment and, when appropriate, switch on cell division and growth. But when the system is faulty, the cyclins over-respond to the growth signals and can cause cancerous growth. The discovery that these proteins aren't indispensable lends encouragement to an idea that blocking overactive cyclins could halt the growth of cancer.

In the Aug. 20 issue of Cell, lead author Katarzyna Kozar, MD, and senior author Peter Sicinski, MD, PhD, report on developing the first mouse embryos to date in which all three D-type cyclins were absent or "knocked out." It had been thought that at least one cyclin was required for an embryo to be viable and its tissues to form normally. Yet the "triple-knockout" mouse embryos followed a normal course of cell division and proliferation until as late as 13.5 days, when most tissues and organs are already formed. A typical mouse pregnancy last 18 days.

(In a companion paper in Cell, researchers from Spain report similar findings involving protein kinases called CDK4 and CDK6, which are molecular partners of the D-cyclins. Embryonic mice with both CDK molecules knocked out had normal tissue development as well.)

The unexpectedly viable embryos contradict theory and previous laboratory experiments. The only abnormality in the triple knockout mice was a deficiency of blood-forming cells, causing them to be pa
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
19-Aug-2004


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study narrows search for genes placing men at increased risk for prostate cancer
9. Study links high carbohydrate diet to increased breast cancer risk
10. Study explains spatial orientation differences between sexes
11. Study suggests humans can speed evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... ... the appointment of Susan Murphy as the new President of Molecular Devices, replacing ... Molecular Devices’ parent company, Danaher Corporation. , Since joining Molecular Devices in a ...
(Date:6/4/2019)... ... 2019 , ... Lajollacooks4u is delighted to announce it has been named as ... is given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, ... , To qualify for the Certificate of Excellence –- an award that only 10 ...
(Date:5/31/2019)... INDIANAPOLIS (PRWEB) , ... May 29, 2019 , ... ... and configurations on Mac, Windows and mobile, announces the launch of version 13.1. ... via the latest Android Management API, and supports Apple’s spring release functionality. Version ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... DES MOINES, Iowa (PRWEB) , ... July 08, 2019 , ... ... in Des Moines, Iowa, the National Corn Growers Association (NCGA) announced the ... unique technology to improve a product or process using field corn to produce biobased ...
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured in ... on regenerative veterinary medicine as a means of improving the quality of life for ... Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it received ...
(Date:6/18/2019)... , ... June 17, 2019 , ... ... they have entered into an agreement for production and manufacturing of GMP-grade adeno-associated ... treatment of rhodopsin-mediated autosomal dominant retinitis pigmentosa (RHO-adRP) and IC-200 for the treatment ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, ... been signed. The agreement will grant exclusive rights for Zillion to represent LDA ...
Breaking Biology Technology:
Cached News: