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Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles

shows antigen on its surface to T cells to prompt an immune system response. Researchers have been exploring whether peptide-based vaccines can induce effective T cell responses, particularly in cancers.

Otvos's research is early-stage, and it remains to be seen whether his designer antimicrobial peptide analogs will be useful in activating dendritic cells as part of an immune therapy. He continues to explore both its general use as a drug-delivery vehicle and its specific use in activating the immune system in future studies.

With Otvos, the co-authors of the paper are: Mare Cudic, formerly of Wistar and Chaperone Technologies, and Brendon Y. Chua, Georgia Deliyannis, and David C. Jackson, all of the University of Melbourne, Australia. Funding for the research was provided by the Commonwealth Universal Research Enhancement Program, Pennsylvania Department of Health, and the National Health and Medical Research Council of Australia.


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Contact: Marion Wyce
wyce@wistar.upenn.edu
215-898-3943
The Wistar Institute
8-Apr-2004


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