HOME >> BIOLOGY >> NEWS
Study suggests mechanism for heart defect that kills young athletes

The most common cause of sudden death in young athletes a heart condition known as hypertrophic cardiomyopathy can develop from a single genetic mutation that disrupts at least two other genes, interfering with the normal beating of the heart, UCSF-led research suggests. All three genes encode contractile proteins that interact in heart muscle.

Hypertrophic cardiomyopathy affects one person in 500, and genetic defects are thought to be responsible for at least half of all cases. Although mutations in a gene for a contractile protein known as cardiac troponin T, or TNNT2 --have been identified in 15 percent of these cases, how the mutations cause disease has not been determined.

The genes function cant be easily explored by traditional knockout methods in mice, since this would kill the embryo as soon as the heart begins to develop. But another animal, the inch-long zebrafish, revealed the answers. Using radiation to create random mutations in the zebrafish genome and then tracking their impact in the embryo, the scientists discovered an embryo whose heart does not beat, which they dubbed silent heart.

With genetic techniques they found that the silent heart gene encodes the zebrafish counterpart of TNNT2. A lack of the protein in the embryos, they discovered, leads to reduced expression of two other contractile proteins, which like TNNT2 are necessary for formation of the sarcomere, the fundamental unit of heart contraction. The research shows for the first time that TNNT2 is essential for the heart to beat.

The finding leads to a new model of what might be going wrong in cardiac sudden death of young athletes. This little fish seems to have a lot to teach us, said Didier Stainier, PhD, UCSF associate professor of biochemistry and biophysics and senior author of a paper on the research in Nature Genetics.

The study will be published online April 22 by Nature Genetics ( http://ww
'"/>


Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
21-Apr-2002


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... 27, 2017 , ... Indiana-based Xylogenics announced today the release ... process. The efficiencies created by the newest strain design will have an ... industry wherein individual production plants are planning to invest upwards of $350 million ...
(Date:6/26/2017)... ... ... The Workgroup for Electronic Data Interchange (WEDI) , the nation’s leading nonprofit ... and a statutory advisor to the U.S. Department of Health and Human Services (HHS), ... Coordinator for Health Information Technology, will deliver the keynote at its 2017 Summer Forum ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... Ken Hanson, ... president of Physik Instrumente USA, have been selected as this year’s recipients of two ... The two have been invited along with other honorees to accept their awards at ...
(Date:6/22/2017)... Colorado (PRWEB) , ... June 21, 2017 , ... ... RTP regional office in North Carolina, and engages Timothy Reinhardt to manage the ... of quality leadership at Pfizer Inc, with his most recent role as the ...
Breaking Biology Technology:
Cached News: