HOME >> BIOLOGY >> NEWS
Subtle Changes In Brain Receptor Gene May Have Significant Consequences For Addiction

Scientists have identified five slightly different versions of the mu opioid receptor gene that alter the activity of a molecule called beta-endorphin, a member of the endorphin family of proteins that can numb pain, create feelings of euphoria or increase energy, which opiates and other drugs of analgesia and addiction do as well. The findings, reported by researchers from The Rockefeller University, Indiana University School of Medicine and University of Cincinnati College of Medicine in the August 4 Proceeding of the National Academy of Sciences, show for the first time that these altered molecules are distributed differently among ethnic groups and have implications for normal physiology, therapeutics and vulnerability to develop or protect from diverse diseases involving mu opioid receptors, including the addictive diseases.

"These findings are potentially very important because of the high frequency of two versions, or alleles, of this gene in the general population," says co-senior author Mary Jeanne Kreek, M.D., professor and head of the Laboratory on the Biology of Addictive Diseases at Rockefeller. "We have defined alterations in the function of one allele studied for both binding and activity."

"These interesting pre-clinical findings present a very important target for additional research into what makes people vulnerable to addictive diseases," says Alan I. Leshner, Ph.D., director of the National Institute on Drug Abuse (NIDA) of the National Institutes of Health, which funded part of the study.

The scientists studied variations in the DNA sequence of the mu opioid receptor gene called single-nucleotide polymorphisms (SNPs). The double-helical structure of DNA comprises four building blocks called nucleotides, represented by the letters A, T, G and C. The nucleotides pair-A with T, G with C-to form limitless combinations along the double helix. SNPs derive from single differences in the base pairing, which may produce changes in the pro
'"/>

Contact: Joseph Bonner
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
4-Aug-1998


Page: 1 2 3

Related biology news :

1. Subtle Biotic Changes Have Big Environmental Impact
2. Changes to insect-seeking calls of horseshoe bats may drive new species formation
3. Changes in shape of single protein plays key role in the spread of cancer cells
4. Changes in arctic ice affect life around the globe
5. Changes in jet stream, storm tracks, linked to prairie drought patterns, study finds
6. Changes in prevalence of mutations associated with HIV treatment failure
7. Changes in rainfall patterns spur plant growth, carbon absorption across U.S.
8. Changes in agricultural practices help clean up Lake Erie
9. Changes in Lake Erie fish population suggest lakes recovery
10. Changes in Australian ecosystems tied to arrival of exotic animals
11. Changes in North American land use have had major impact on global environment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... LONDON (PRWEB) , ... February ... ... Science announce an agreement that will see Dimensions rolled out across the ... more informed data-driven decisions across their business, support strategic planning, and understand ...
(Date:2/19/2019)... ... February 19, 2019 , ... ... Mark Hozza as Chief Commercial Officer of the life science research and advisory ... performance, strategy, and alignment of all market research and media revenue operations in ...
(Date:2/19/2019)... ... February 18, 2019 , ... ... delivery technologies and development solutions for drugs, biologics and consumer health products, ... highest external business partner recognition, the External Business Partner of the Year ...
Breaking Biology News(10 mins):
(Date:2/19/2019)... ... ... VetStem Biopharma has long been a leader in veterinary stem ... the formation of Personalized Stem Cells, Inc (“PSC”), a human adipose stem cell company. ... to launch into human stem cell clinical therapy. PSC will conduct a series ...
(Date:2/16/2019)... ... February 14, 2019 , ... DaVinci is a ... that also provides the flexibility for users to bring their own data and ... shared workbench to conduct quick analytics on near-real-time data to gain timely insights ...
(Date:2/14/2019)... ... February 14, 2019 , ... ... leak testing systems for the pharmaceutical, biotechnology and food industries, formally announced today ... Brian Mulhall has been named Chief Executive Officer and will oversee ...
(Date:2/12/2019)... SAN FRANCISCO (PRWEB) , ... February 12, 2019 ... ... (CRO) specializing in dermatology, has finalized a deal to extend their use of ... diagnostics clinical trials, through 2023. The CRO has been a regular Medrio customer ...
Breaking Biology Technology:
Cached News: