HOME >> BIOLOGY >> NEWS
Supercomputer paints electric landscape of cellular structures

Researchers create atomic-resolution maps of microtubules and ribosomes

SAN DIEGO, CA-Researchers at the University of California, San Diego have mapped key cellular structures using a new method to harness the power of supercomputing. The maps may point the way to understanding how those structures perform functions such as transporting a drug like taxol to a binding site so it can do its work in treating breast cancer.

"We've achieved a new landmark in the scale of cellular structures that we can model from a molecular perspective," said J. Andrew McCammon, Joseph E. Mayer Professor of Theoretical Chemistry at UCSD and an Howard Hughes Medical Institute investigator. "The work signals a new era of calculations on cellular-scale structures in biology."

The researchers created a new method for solving what is known as known as the Poisson-Boltzmann equation. This allowed them to increase the size of the systems they could model from less than 50,000 atoms to over an unprecedented million atoms. McCammon likened the ability to pick out one atom within such a large three-dimensional system as being able to specifically describe one cherry within an entire fruit tree.

The maps depict an atom-by-atom rendering of the electrostatic potential of structures found within cells: microtubules, which are involved in intracellular transport and shape, and ribosomes, which manufacture proteins. Electrostatics describe the way in which the landscape of electrical charge is laid out in a molecular environment, for example, the electric forces that draw a taxol molecule through a microtubule and into a binding site or that tug a tRNA molecule into place on a ribosome during translation.

The calculations were performed at the San Diego Supercomputer Center (SDSC) at UCSD on Blue Horizon, a large IBM SP supported by the National Partnership for Advanced Computational Infrastructure (NPACI). The work will appear online in the Proceedi
'"/>

Contact: Cassie Ferguson
cferguson@sdsc.edu
858 822-3622
University of California - San Diego
20-Aug-2001


Page: 1 2 3

Related biology news :

1. Research on lead poisoning, hair styling and artists oil paints will be featured at Towson University gathering of worlds largest scientific society
2. Cleaner water, more efficient electricity among UH chemical research
3. Microbial fuel cell cleans, generates electricity from domestic wastewater
4. Scientists decode DNA of bacterium that cleans up uranium contamination and generates electricity
5. Scientists decipher genome of bacterium that remediates uranium contamination, generates electricity
6. DNAs oscillating double helix hinders electrical conduction
7. Sea Grant research shows electric barrier may stop Asian carp
8. Hopkins scientists reveal how sound becomes electric
9. UMass study uses microbes to turn mud into electricity
10. Deregulation will cause significant fluctuations in electricity prices, new study reveals
11. UF researchers find painless electrical stimulus helps restore hand movement for stroke patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... MELBOURNE, Florida , April 11, 2017 ... "Company"), a security technology company, announces the appointment of independent ... John Bendheim to its Board of Directors, furthering the ... ... behalf of NXT-ID, we look forward to their guidance and ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/9/2017)... Antonio, Texas (PRWEB) , ... ... ... new study published on October 5, 2017, in the medical journal, Epilepsia, ... equivalence with the gold standard, video EEG, in detecting generalized tonic-clonic seizures ...
(Date:10/6/2017)... Boston, Mass. (PRWEB) , ... October 06, 2017 ... ... spotlight female entrepreneurship within the healthcare and technology sector at their fourth annual ... six panels featuring 30 inspiring speakers and the ELEVATE pitch competition showcasing early ...
Breaking Biology Technology:
Cached News: