Susceptibility Genes For Nicotine Addiction

Susceptibility genes for nicotine dependence: a genome scan and follow-up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.

Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors have been conclusively show to influence both smoking initiation and nicotine dependence, but none of the genes involved have yet been conclusively identified. A genome scan was conducted to identify chromosomal regions linked to nicotine dependence in a collection of 130 families containing 308 nicotine dependent individuals from Christchurch, New Zealand. The best evidence for linkage was found with a marker on chromosome two which resulted in a heterogeneity LOD score of 2.63.

To identify regions that warranted further study, we compared them to an empirical baseline, and found modest evidence for linkage on chromosomes 2, 4, 10, 16, 17 and 18. These were investigated by additional genotyping of the Christchurch sample and by examination in an independent sample from Richmond, Virginia (91 families with 211 nicotine dependent individuals).

Analysis of the Richmond provided limited additional evidence for linkage, particularly in regions on chromosomes 2, 10, 16, 17 and 18. The sample sizes used here provide only limited power to detect linkage for a genetically complex trait such as nicotine dependence. Therefore, some or all of the most positive results could be due to chance. However, the evidence for limited replication in several regions across the two samples suggests that some of these regions may contain genes influencing nicotine dependence and therefore deserve further study.


Contact: Julie Vianello
Molecular Psychiatry

Page: 1

Related biology news :

1. Susceptibility of mice to mousepox offers promise of smallpox protection
2. Researchers Discover Tumor-Supressor Gene That May Indicate Susceptibility ToLung And Colon Cancer
3. Study Shows First Significant Genetic Evidence For Schizophrenia Susceptibility
4. Rockefeller University Researchers Hunt For Type 2 Diabetes Susceptibility Genes
5. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
6. Genes expose secrets of sex on the side
7. Genes can influence both alcohol consumption and dependence
8. Genes may be central to cocaine addiction
9. Genes appear to play a role in development of chronic obstructive pulmonary disease
10. Genes make the marsh
11. Genes predict response of adult leukemia patients to chemotherapy

Post Your Comments:

(Date:11/9/2015)... JOSE, Calif. , Nov. 9, 2015  Synaptics ... human interface solutions, today announced broader entry into the ... vehicle-specific solutions that match the pace of consumer electronics ... and biometric sensors are ideal for the automotive industry ... vehicle. Europe , ...
(Date:10/29/2015)... , Oct. 29, 2015   MedNet Solutions ... the entire spectrum of clinical research, is pleased to ... High Tech Association (MHTA) as one of only three ... the "Software – Small and Growing" category. The Tekne Awards ... who have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... 2015  Rubicon Genomics, Inc., today announced an ... its DNA library preparation products, including the ThruPLEX ... Plasma-seq kit. ThruPLEX Plasma-seq has been optimized for ... libraries for liquid biopsies--the analysis of cell-free circulating ... in cancer and other conditions. Eurofins Scientific is ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... Santa Clara, CA (PRWEB) , ... December 01, ... ... Atomic Force Microscopy (AFM) announces Park NX10 SICM Module, an add-on scanning ion ... that easily integratesthe power of SICM to an AFM. , Park SICM benefits ...
(Date:12/1/2015)... 2015 Dr. Harry Lander , President of Regen, ... Chief Science Officer and recruits five distinguished ... , President of Regen, expands his role to include ... five distinguished scientists to join advisory team --> ... role to include serving as Chief Science ...
(Date:11/30/2015)... ... November 30, 2015 , ... Global Stem Cells Group announced ... new closed system for isolating adipose-derived stem cells. The announcement starts a new phase ... tissue. SVF is a component of the lipoaspirate obtained from liposuction of excess adipose ...
(Date:11/30/2015)... 2015 Partnership includes an MPP ... for the u niversity , s ... treatment s cale - up through ... Africa , where licensees based anywhere in the world will have ... --> Africa , where licensees based anywhere in the world ...
Breaking Biology Technology:
Cached News: