Susceptibility Genes For Nicotine Addiction

Susceptibility genes for nicotine dependence: a genome scan and follow-up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.

Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors have been conclusively show to influence both smoking initiation and nicotine dependence, but none of the genes involved have yet been conclusively identified. A genome scan was conducted to identify chromosomal regions linked to nicotine dependence in a collection of 130 families containing 308 nicotine dependent individuals from Christchurch, New Zealand. The best evidence for linkage was found with a marker on chromosome two which resulted in a heterogeneity LOD score of 2.63.

To identify regions that warranted further study, we compared them to an empirical baseline, and found modest evidence for linkage on chromosomes 2, 4, 10, 16, 17 and 18. These were investigated by additional genotyping of the Christchurch sample and by examination in an independent sample from Richmond, Virginia (91 families with 211 nicotine dependent individuals).

Analysis of the Richmond provided limited additional evidence for linkage, particularly in regions on chromosomes 2, 10, 16, 17 and 18. The sample sizes used here provide only limited power to detect linkage for a genetically complex trait such as nicotine dependence. Therefore, some or all of the most positive results could be due to chance. However, the evidence for limited replication in several regions across the two samples suggests that some of these regions may contain genes influencing nicotine dependence and therefore deserve further study.


Contact: Julie Vianello
Molecular Psychiatry

Page: 1

Related biology news :

1. Susceptibility of mice to mousepox offers promise of smallpox protection
2. Researchers Discover Tumor-Supressor Gene That May Indicate Susceptibility ToLung And Colon Cancer
3. Study Shows First Significant Genetic Evidence For Schizophrenia Susceptibility
4. Rockefeller University Researchers Hunt For Type 2 Diabetes Susceptibility Genes
5. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
6. Genes expose secrets of sex on the side
7. Genes can influence both alcohol consumption and dependence
8. Genes may be central to cocaine addiction
9. Genes appear to play a role in development of chronic obstructive pulmonary disease
10. Genes make the marsh
11. Genes predict response of adult leukemia patients to chemotherapy

Post Your Comments:

(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  The Prostate Cancer Foundation (PCF) is pleased ... and faster cures for prostate cancer. Members of the Class of 2016 were ... Read More About the Class of 2016 PCF Young ... ... ...
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. Hays ... DNA as a Field Application Specialist. , “I am thrilled that Dr. Young ... DNA. “In further expanding our capacity as a scientific integrator, Hays brings a wealth ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
Breaking Biology Technology:
Cached News: