HOME >> BIOLOGY >> NEWS
Susceptibility Genes For Nicotine Addiction

Susceptibility genes for nicotine dependence: a genome scan and follow-up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study.

Cigarette smoking is associated with considerable morbidity, mortality, and public health costs. Genetic factors have been conclusively show to influence both smoking initiation and nicotine dependence, but none of the genes involved have yet been conclusively identified. A genome scan was conducted to identify chromosomal regions linked to nicotine dependence in a collection of 130 families containing 308 nicotine dependent individuals from Christchurch, New Zealand. The best evidence for linkage was found with a marker on chromosome two which resulted in a heterogeneity LOD score of 2.63.

To identify regions that warranted further study, we compared them to an empirical baseline, and found modest evidence for linkage on chromosomes 2, 4, 10, 16, 17 and 18. These were investigated by additional genotyping of the Christchurch sample and by examination in an independent sample from Richmond, Virginia (91 families with 211 nicotine dependent individuals).

Analysis of the Richmond provided limited additional evidence for linkage, particularly in regions on chromosomes 2, 10, 16, 17 and 18. The sample sizes used here provide only limited power to detect linkage for a genetically complex trait such as nicotine dependence. Therefore, some or all of the most positive results could be due to chance. However, the evidence for limited replication in several regions across the two samples suggests that some of these regions may contain genes influencing nicotine dependence and therefore deserve further study.


'"/>

Contact: Julie Vianello
j.vianello@stockton-press.co.uk
301-496-6979
Molecular Psychiatry
1-Mar-1999


Page: 1

Related biology news :

1. Susceptibility of mice to mousepox offers promise of smallpox protection
2. Researchers Discover Tumor-Supressor Gene That May Indicate Susceptibility ToLung And Colon Cancer
3. Study Shows First Significant Genetic Evidence For Schizophrenia Susceptibility
4. Rockefeller University Researchers Hunt For Type 2 Diabetes Susceptibility Genes
5. Duke Researchers Discover Candidate Susceptibility Gene For Autoimmune Disease
6. Genes expose secrets of sex on the side
7. Genes can influence both alcohol consumption and dependence
8. Genes may be central to cocaine addiction
9. Genes appear to play a role in development of chronic obstructive pulmonary disease
10. Genes make the marsh
11. Genes predict response of adult leukemia patients to chemotherapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... will be hosting a Webinar titled, “Pathology is going digital. Is your lab ... digital pathology adoption best practices and how Proscia improves lab economics and realizes ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking events ... announced today. The bold new look is part of a transformation to increase ... a significant growth period. , It will also expand its service offering from its ...
Breaking Biology Technology:
Cached News: