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Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents

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"Such a large dose may have inundated the physiological system, negating any differences that might have been seen with lower doses," said Jialal, who is also a professor of pathology and internal medicine.

In a randomized, placebo-controlled study of 79 healthy patients, Jialal and colleagues tested doses of 100, 200, 400, and 800 IUs of natural and synthetic vitamin E for eight weeks.

There was significantly less oxidation of LDL in the groups that received 400 or 800 IUs of natural or synthetic vitamin E. There was no significant change in the groups that received a placebo, 100 or 200 IUs of either form of the vitamin.

The results also confirmed earlier work by Jialal, who had found that a minimum dose of 400 IUs of vitamin E is necessary to induce the antioxidant effect.

"In heart patients taking a minimum daily dose of 400 IUs of vitamin E, it doesn't appear to matter if it's natural or synthetic," he said.

None of the subjects reported adverse effects from supplementation with either the natural or synthetic form.

Also contributing to the study were Beverly Adams-Huet, a biostatistician in the General Clinical Research Center at UT Southwestern, and Cindy Fuller, now an assistant professor at the University of North Carolina at Greensboro.

The research was funded by grants from Henkel Corp. and the National Institutes of Health.


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Contact: Bridgette Rose McNeill
bmcnei@mednet.swmed.edu
214-648-3404
UT Southwestern Medical Center
17-Oct-1997


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