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Synthetic antifreeze could prevent ice growth

A fish swimming in icy polar waters is helping scientists find ways to protect food from freezer burn, save fruit crops from frost, and use low temperature storage in complicated medical procedures like human organ transplants, researchers report.

A way to make large amounts of artificial antifreeze safe enough to use in living organisms has been developed by researchers looking at the biological antifreeze used by Arctic and Antarctic teleost fish, according to a report in the September/October issue of Bioconjugate Chemistry, a peer-reviewed journal of the American Chemical Society, the worlds largest scientific society. The report will be presented August 30 at the Societys 222nd national meeting in Chicago.

A big problem with the freezing process in medical and industrial applications is that the formation of ice crystals damages living material. Certain organisms like the fish, however, have developed a successful defense a naturally produced antifreeze called antifreeze glycoprotein, or AFGP. The biological AFGP in fish, and in some amphibians, plants and insects, prevents the growth of ice in those life forms, scientists have found.

While researchers have known about the glycoproteins for many years, they have been unable to produce large or stable enough copies for commercial applications, and the use of the natural compounds themselves is too labor and cost-intensive to be practical.

Even though researchers do not precisely understand the mechanism by which the AFGPs function, they have been able to modify the structure of the fish AFGP enough to build a longer lasting mimic, a lot like the native AFGPs, according to Robert Ben, Ph.D., who led the research team from the State University of New York in Binghamton. Ben says the new method can easily produce large quantities of the compound that yield only to inhospitable conditions like extremely high or low temperatures.

The new synthetic proteins are dramatic
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Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
19-Aug-2001


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