HOME >> BIOLOGY >> NEWS
Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies

ATLANTA -- Medroxyprogesterone acetate (MPA), a synthetic form of the naturally occurring steroid hormone progesterone widely used in contraceptives and hormone replacement therapy (HRT), increases aggression and anxiety and reduces sexual activity in female monkeys, according to a study published in the June edition of The Journal of Clinical Endocrinology and Metabolism. The investigators, from the Yerkes National Primate Research Center of Emory University and the Center for Behavioral Neuroscience (CBN) in Atlanta, say the findings may explain anecdotal reports of mood changes, depression and loss of libido in some women who use MPA for contraception and HRT.

In the counter balanced-designed study, Yerkes and CBN post-doctoral fellow Karen Pazol, PhD, compared aggression, anxiety and sexual behavior in six female pigtail macaques that received one week each of three different treatments: estrogen only, estrogen plus natural progesterone, and estrogen plus MPA.

Monkeys displayed significantly more aggressive and anxious behaviors when they received the estrogen/MPA combination as compared to when they received the estrogen only or the estrogen/progesterone combination. Dr. Pazol also noted a marked reduction in sexual activity during the estrogen/MPA treatment period.

"Our findings suggest MPA may be affecting certain neuroendocrine systems in a very different way than natural progesterone," explained Dr. Pazol. "In comparison to natural progesterone, MPA binds to glucocorticoid receptors with a much higher affinity and may have a greater impact on the brain's stress system."

Moreover, according to Dr. Pazol, unlike natural progesterone, MPA cannot be converted to the mood-regulating chemical, allopregnanolone. Changes in allopregnanolone levels have been associated with depression, anxiety disorders and premenstrual mood disorders in humans.

To identify MPA's behavioral e
'"/>

Contact: Kelly Thompson
kthomp8@emory.edu
404-727-9254
Emory University Health Sciences Center
7-Jun-2004


Page: 1 2

Related biology news :

1. Synthetic antifreeze could prevent ice growth
2. Synthetic clay could assist radioactive waste cleanup
3. New Class Of Synthetic Capsules That Mimic Biological Cells Has Wide Array Of Potential Uses
4. Synthetic Lock Binds Some Molecules, Excludes Others
5. A Synthetic Peptide Destroys Brain Plaque Implicated in Alzheimers Disease
6. Cellular Engineers Design Custom Cell Surfaces Able To Adhere To Synthetic Materials
7. Synthetic Vitamin E And Natural Vitamin E Are Equally Powerful Antioxidents
8. Growth hormone and IBD: Reduction of intestinal inflammation, promotion of growth
9. Excess thyroid hormone harmful to fetus
10. Blood pressure hormone may inhibit growth of lung cancer
11. Hunt for a new plant hormone points to carotenoids

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... 23, 2020 , ... Rigaku Corporation , a global ... a series of TOPIQ webinars, which will cover the Transferable Aspherical Atom Model ... response to social distancing measures that resulted in postponements and cancelations of global ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... Your Lab with Software for Data Decisions,” for pharmaceutical and biotech executives, ... integrate and automate cutting-edge scientific instruments and laboratory equipment from dozens of ...
(Date:6/11/2020)... (PRWEB) , ... June 08, 2020 , ... ... for masks and other protective measures to protect workers in the medical field. ... their dedicated staffs who valiantly risk their lives every day to provide healthcare ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... , ... July 09, 2020 , ... ... 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining ... research team led by Dr MA has been using the zebrafish model to ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:6/28/2020)... Calif. (PRWEB) , ... June 25, 2020 , ... ... researchers are racing to develop a vaccine or drug treatment. In an effort ... Recursion has publicly released the world’s largest imaging dataset portraying therapeutic compound ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... solutions in complex indoor environments, announced today that Derek Fournier has been appointed ... of Chairman of the Board, effective immediately. , “DeCurtis Corporation has been ...
Breaking Biology Technology:
Cached News: