HOME >> BIOLOGY >> NEWS
Syphilis Genome Sequence Offers Clues To Better Diagnosis, Prevention And Treatment

In a research breakthrough that paves the way for preventive vaccines as well as better diagnostic tests and treatments, scientists have sequenced the complete genome for Treponema pallidum, the bacterium that causes syphilis.

The project, funded by the National Institute of Allergy and Infectious Diseases (NIAID), was a collaboration between scientists led by George M. Weinstock, Ph.D., and Steven J. Norris, Ph.D., at the University of Texas Health Science Center in Houston, and Claire M. Fraser, Ph.D., and colleagues at The Institute for Genomic Research in Rockville, Md. They report their findings in the July 17, 1998, issue of Science.

A serious, potentially fatal sexually transmitted disease, syphilis once caused widespread epidemics and is still a major cause of illness and death around the world. People with syphilis lesions also are at higher risk for HIV infection. Although reported syphilis cases in the United States are at an all-time low, outbreaks still occur especially in inner cities and the rural South. Syphilis can be treated with injections of penicillin or other antibiotics - but the early symptoms can be mild or absent, so that many people do not seek treatment when they first become infected.

The new genetic map of T. pallidum should make it easier for scientists to fill some remaining gaps in detection, treatment and prevention. A major problem for researchers has been the inability to grow the organism in the laboratory. The genetic map identifies genes that are present or absent in the bacterium's metabolic pathways. "This critical information will allow us to develop better drugs, a continuous laboratory culture system and a specific diagnostic test," says Penelope J. Hitchcock, D.V.M., chief of the sexually transmitted diseases branch at NIAID.

Adds NIAID Director Anthony S. Fauci, M.D., "Completion of this project is an extraordinary boost for efforts to develop a protective vaccine."

Syphilis is difficult to
'"/>

Contact: June R. Wyman
jwyman@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
16-Jul-1998


Page: 1 2 3

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Genome-wide screen reveals new tricks of old genes
3. Genome of first fungal pathogen unveiled
4. Experimental Biology 2004 - Translating the Genome
5. European Virtual Institute for Genome Annotation receives 12 million Euro
6. Tools from the Human Genome Project reveal a versatile microbe
7. Francis Collins and Ari Patrinos receive Energy Secretarys Gold Award for Human Genome Project
8. Genomes of tiny microbes yield clues to global climate change
9. Genome researcher analyze chromosome 7
10. Genome sequence of bread mold revealed by international team, including Hebew University researcher
11. Genome analysis sheds light on drug-resistant pathogen

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/5/2019)... Calif. (PRWEB) , ... July 05, 2019 , ... ... with Microsoft to bring its patented Tractus™ Platform to governments around the world. ... bring cutting edge technology and point of care solutions to operating theatres worldwide ...
(Date:6/20/2019)... ... June 19, 2019 , ... The half-million dollars ... of America Foundation, and the possibly millions of dollars of “high priority” grants ... AD, are a “welcome affirmation” of the need to investigate more thoroughly the ...
(Date:6/16/2019)... ... , ... Emtec, Inc.®, a global IT and management consulting ... CIO at the Healthcare Industry User Group (HIUG) Interact 2019 in ... President and Chief Information Officer, Lynne Briggs, will present Versiti’s Oracle Cloud Success ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine ... Pharm: Where Beasts Meet Biotech. The film focuses on regenerative veterinary medicine as ... Animal Pharm was recently included in the Brentwood and Pacific Palisades International ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... ROANOKE, Va. (PRWEB) , ... June 11, 2019 ... ... for microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, announced ... in virtual care. , Mytonomy recently deployed its virtual care platform ...
(Date:5/31/2019)... ... ... For many years, the primary forms of cancer treatment have been chemotherapy, radiation ... have led to the advent of Chimeric Antigen Receptor T (CAR T) cell therapy, ... “CARs”. The CAR enables the final product to produce chemicals in the hopes that ...
Breaking Biology Technology:
Cached News: