Syphilis Genome Sequence Offers Clues To Better Diagnosis, Prevention And Treatment

diagnose, treat and prevent:


Symptoms can be mild or absent in the early stages, and early symptoms mimic those of many other diseases. Moreover, interpreting blood tests can be difficult - the tests can give false negative results for up to three months after infection - and repeated tests are often needed to confirm the diagnosis. "For example, with the current screening test, people who have yaws will test positive for syphilis," says Dr. Hitchcock. "In addition, we need a specific test that will diagnose congenital syphilis."

Scientists can use the genetic blueprint for T. pallidum to devise diagnostic tests that are more specific, more accurate and easier to use.


Syphilis is treated with injections of penicillin or other antibiotics. About 10 percent of the population is allergic to penicillin; others do not respond to the usual doses and may need repeated injections. Easy-to-administer treatments that do not require an injection are needed, especially for use in developing countries.

The genetic blueprint for the syphilis bacterium suggests targets for new, more specific antibiotics.


As for other sexually transmitted diseases, preventing syphilis requires constant vigilance, such as using condoms during intercourse and avoiding contact with an infected person's open sores. Moreover, for syphilis as well as some other sexually transmitted diseases, the male condom is only partially protective. That is because the sores can be in places that are not covered by the condom.

Thus preventing syphilis requires extensive screening and treatment. A vaccine would be the easiest, most practical and effective method of prevention, and is especially needed to prevent new infections in high-risk U.S. populations and in developing countries.

The genome sequence for T. pallidum reveals the existence of 12 membrane (surface) proteins that could be tested in experimental vaccines. One o

Contact: June R. Wyman
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Genome-wide screen reveals new tricks of old genes
3. Genome of first fungal pathogen unveiled
4. Experimental Biology 2004 - Translating the Genome
5. European Virtual Institute for Genome Annotation receives 12 million Euro
6. Tools from the Human Genome Project reveal a versatile microbe
7. Francis Collins and Ari Patrinos receive Energy Secretarys Gold Award for Human Genome Project
8. Genomes of tiny microbes yield clues to global climate change
9. Genome researcher analyze chromosome 7
10. Genome sequence of bread mold revealed by international team, including Hebew University researcher
11. Genome analysis sheds light on drug-resistant pathogen

Post Your Comments:

(Date:6/4/2019)... TORONTO (PRWEB) , ... June 04, 2019 , ... ... automate the search for salient features of seizure risk signals, usually based on ... neurologist-driven EEG interpretation remains the only acceptable diagnostic methodology due to the complexity ...
(Date:6/1/2019)... ... May 31, 2019 , ... ... & Rosati recently invested in BioFactura’s $6M Series B Financing Round. , ... value-added institutional investors who bring significant financial and business resources to bear as ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... (PRWEB) , ... July 02, 2019 , ... Leading Regenerative ... entitled Animal Pharm: Where Beasts Meet Biotech. The film focuses on regenerative veterinary ... animals. Animal Pharm was recently included in the Brentwood and Pacific ...
(Date:6/11/2019)... ... 2019 , ... Thought Technology Ltd is pleased to announce ... Tech Ltd as its authorised distributor for the UK and Ireland. , ... and clinical assessment protocols to treat stress related disorders as well as provide ...
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
Breaking Biology Technology:
Cached News: