Syphilis Genome Sequence Offers Clues To Better Diagnosis, Prevention And Treatment

diagnose, treat and prevent:


Symptoms can be mild or absent in the early stages, and early symptoms mimic those of many other diseases. Moreover, interpreting blood tests can be difficult - the tests can give false negative results for up to three months after infection - and repeated tests are often needed to confirm the diagnosis. "For example, with the current screening test, people who have yaws will test positive for syphilis," says Dr. Hitchcock. "In addition, we need a specific test that will diagnose congenital syphilis."

Scientists can use the genetic blueprint for T. pallidum to devise diagnostic tests that are more specific, more accurate and easier to use.


Syphilis is treated with injections of penicillin or other antibiotics. About 10 percent of the population is allergic to penicillin; others do not respond to the usual doses and may need repeated injections. Easy-to-administer treatments that do not require an injection are needed, especially for use in developing countries.

The genetic blueprint for the syphilis bacterium suggests targets for new, more specific antibiotics.


As for other sexually transmitted diseases, preventing syphilis requires constant vigilance, such as using condoms during intercourse and avoiding contact with an infected person's open sores. Moreover, for syphilis as well as some other sexually transmitted diseases, the male condom is only partially protective. That is because the sores can be in places that are not covered by the condom.

Thus preventing syphilis requires extensive screening and treatment. A vaccine would be the easiest, most practical and effective method of prevention, and is especially needed to prevent new infections in high-risk U.S. populations and in developing countries.

The genome sequence for T. pallidum reveals the existence of 12 membrane (surface) proteins that could be tested in experimental vaccines. One o

Contact: June R. Wyman
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3

Related biology news :

1. Wiley publishes Welcome to the Genome: A Users Guide to the Genetic Past, Present, and Future
2. Genome-wide screen reveals new tricks of old genes
3. Genome of first fungal pathogen unveiled
4. Experimental Biology 2004 - Translating the Genome
5. European Virtual Institute for Genome Annotation receives 12 million Euro
6. Tools from the Human Genome Project reveal a versatile microbe
7. Francis Collins and Ari Patrinos receive Energy Secretarys Gold Award for Human Genome Project
8. Genomes of tiny microbes yield clues to global climate change
9. Genome researcher analyze chromosome 7
10. Genome sequence of bread mold revealed by international team, including Hebew University researcher
11. Genome analysis sheds light on drug-resistant pathogen

Post Your Comments:

(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... Calif. (PRWEB) , ... August ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed their ... CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary focus ...
(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased to announce ... online store are now live. Sierra has redesigned entry to the site with both ... more user-friendly and easier to navigate with streamlined menus and simple access to resources ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Suvoda LLC ... and drug supply chain management, today announced its new technology partnership with ... , “The integration between Veeva Vault EDC and our IRT will enable sponsors ...
(Date:9/8/2019)... , ... September 05, 2019 , ... ... Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named Chief ... and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has hired ...
(Date:8/29/2019)... IN (PRWEB) , ... August 29, 2019 , ... ... a year to teach in the Sustainable Medicines in Africa program, which includes ... will take place in Arusha, Tanzania September 2nd through 13th, 2019. Topics ...
(Date:8/23/2019)... ... August 22, 2019 , ... ... delivery modalities and is scheduled to broadcast 4Q/2019. Check your local listings for ... skin patches for generic drug delivery. Focusing on therapeutics for children and the ...
Breaking Biology Technology:
Cached News: