HOME >> BIOLOGY >> NEWS
Systematic analysis of gene family uncovers new therapeutic targets for colon cancer

Investigators from the Johns Hopkins Kimmel Cancer Center and Howard Hughes Medical Institute have completed what is believed to be the first systematic analysis of a disease-related gene family. Their analysis, reported in the May 9, 2003 issue of Science, uncovered gene mutations, linked to more than 30 percent of colon cancers, which could serve as therapeutic targets.

The research team studied 182 human colon cancers to identify mutations in the tyrosine kinase (TK) gene family. TK genes are thought be good therapeutic targets for managing cancer because the proteins they encode play key roles in controlling cell growth, differentiation, motility, and nearby tissue invasion. Although a few TK genes have been shown to be mutated in specific cancers, until now, no study has revealed how many or how often members of the TK gene family are altered in a particular cancer type, according to Victor E. Velculescu, M.D., Ph.D., assistant professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, who led the research effort.

"Our findings open the door to individualized analysis and treatment of colorectal cancer," says Velculescu.

TKs are so-called activating proteins that, when altered or damaged, signal cells to continually divide and take other actions that can lead to cancer. Drugs such as Gleevec, Herceptin and other inhibitor-class compounds that block the proteins made by mutated TK genes have been shown in both human clinical trials and animal studies to halt the cancer process.

"With this new work," Velculescu says, "one could imagine personalized therapeutics, based on mutations in different kinase genes and designed to match the mutated TK pathways present in each patient's particular tumor DNA."

To conduct this research, the investigators focused on the 138 normal TK genes that all humans contain. They were able to identify mutations in 14 of these genes only after si
'"/>

Contact: Valerie Matthews Mehl
mehlva@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
8-May-2003


Page: 1 2

Related biology news :

1. Systematics at a Crossroads: Biological and Philosophical Arguments
2. Human chromosome 5 final sequence analysis released to public
3. Genetic analysis rewrites salamanders evolutionary history
4. New analysis gives cancer patients personalized prognosis
5. Proven method of bone analysis may clarify human origins
6. Carnegie Mellon U. conducts first comprehensive proteomic analysis of developing animal
7. Online calculator improves analysis of chemical data
8. Scientists discover way to streamline analysis of maize genome
9. Automated analysis of bee behavior may yield better robots
10. High-tech analysis of vineyard soil
11. SARS virus can change quickly and unpredictably, analysis indicates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... The August ... published and is now available on the company’s global website. Crystallography Times—an electronic ... community, presenting current news and crystallographic research. , The latest issue of ...
(Date:8/21/2020)... ... August 19, 2020 , ... ... conference and expo uniting life science, data science, informatics and IT leaders goes ... “In this period of uncertainty and change, Bio-IT takes the leadership role of ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio ... are ideal for public health agencies of all sizes. With a focus on ... at-risk individuals find appropriate health care, Mosio helps public health departments automate communications ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/22/2020)... , ... July 22, 2020 , ... Join experts from ... Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar on ... regulating body in China for drugs and medical devices. Specifically, for medical devices, the ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
Breaking Biology Technology:
Cached News: