HOME >> BIOLOGY >> NEWS
TIGR completes study providing insight into infectious strain of bacterium that causes otitis, pneumonia and meningitis

ROCKVILLE, MD Investigators at The Institute for Genomic Research (TIGR) today announced that they have determined the complete genome sequence of a virulent isolate (a very infectious strain) of Streptococcus pneumoniae or pneumococcus, the bacterium which causes over 3 million children and even more elderly people to die every year from pneumonia or meningitis. It is also the most common cause of otitis media or ear infection.

Herv Tettelin, Ph.D., principal investigator for the project, led the team at TIGR that determined the order of all of the 2.16 million individual chemical base units making up S. pneumoniaes DNA. This study, reported in the July 20 issue of Science, represents the 26th genome sequencing project completed by TIGR.

S. pneumoniae is one of the most significant bacterial pathogens of humans in terms of morbidity and mortality and this situation is compounded by a progressive increase in antibiotic resistance, particularly to penicillin and to other commonly used antibiotics, that has been observed worldwide. This increased resistance complicates the ability to treat pneumococcal infections and is focusing greater attention on prevention strategies. Undoubtedly, the availability of the complete genome sequence will provide additional avenues for follow-up studies on the basic biology and pathogenicity of this important pathogen.

Genome analysis revealed a number of novel insights relevant to the biology of S. pneumoniae including: the observation that 5% of the genome is composed of repeats (pieces of DNA that are found in several locations in the genome) that may facilitate incorporation of foreign DNA into the S. pneumoniae chromosome and contribute to rearranging its structure; the description of a new sequence motif that may be involved in bringing proteins to the surface of the bacteria, including virulence factors and a novel large protein composed of 540 repeat modules that could play a role in adhesion to huma
'"/>

Contact: Sharon Dukes
sdukes@tigr.org
301-610-5969
The Institute for Genomic Research
19-Jul-2001


Page: 1 2

Related biology news :

1. OneWorld Health completes enrollment, treatment in Phase III India trial
2. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
3. NTP completes 500th two-year rodent study and report; series is the gold standard of animal toxicology
4. DoubleTwist completes the first annotation of the human genome
5. Student science contest participation influences study, career choices, alumni say
6. New study shows hope for treating inhalant abuse
7. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
8. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
9. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
10. Phase II trials of second-generation antisense cancer drug planned following successful early study
11. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: