Tamoxifen's effectiveness may be compromised by hot flash drug

The effects of tamoxifen, a therapy used in the treatment and prevention of breast cancer, may be limited by the use of a commonly prescribed drug to prevent side effects of the treatment, according to a study published in the Dec. 3 issue of the Journal of the National Cancer Institute.

"Our study suggests that tamoxifen's metabolism, and possibly its effectiveness, can be modified by the genetic makeup of the person taking the drug and by the use of another drug prescribed to reduce tamoxifen-related hot flashes," says the study's senior author David Flockhart, M.D., Ph.D., director of the Division of Clinical Pharmacology at the Indiana University School of Medicine. "Our conclusions indicate that more extensive research is appropriate."

Tamoxifen, a drug that modifies the effect of estrogen on cells, is widely and effectively used in many women as part of standard therapy for those with breast cancer and those at high risk of developing the disease. For about 80 percent of the women who take tamoxifen, hot flashes are a side effect of the therapy and 45 percent of those women rate them as severe.

Drugs commonly prescribed to remedy the problem are new antidepressants, paroxetine and fluoxetine, which are selective serotonin reuptake inhibitors (SSRIs). SSRIs have been shown to inhibit the enzyme that breaks down tamoxifen into chemical agents called metabolites, including 4-hydroxy-tamoxifen, which was believed to be tamoxifen's most active metabolite.

Twelve women with a history of breast cancer, but no current evidence of the disease, were enrolled in a yearlong clinical trial. The women had to have taken tamoxifen for four weeks prior to enrolling in the trial, and remained on the therapy until the trial's conclusion. Each woman also took paroxetine for four weeks.

Extensive laboratory analysis of the women's blood plasma showed a significant decrease in a metabolite of tamoxifen after treatment with paroxetine.

Contact: Mary Hardin
Indiana University

Page: 1 2

Related biology news :

1. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
2. Gene chips help gauge chemotherapys effectiveness in adult leukemia patients
3. NIH consensus panel confirms effectiveness of total knee replacement
4. Drug that mimics vitamin D hormone may boost effectiveness of prostate cancer treatment
5. Rb2 gene may play role in determining effectiveness of drug therapies against breat cancer
6. Antibody therapy can increase the effectiveness of cancer vaccine, early studys
7. Nutrition and exercise boost effectiveness of flu shot in older people
8. Smart carriers and tiny skin-deep medicine cabinets improve drug effectiveness against cancer, AIDS, other diseases
9. Like grapefruit, sour oranges boost drug effectiveness, scientists find, and also why
10. High cholesterol hinders the effectiveness of aspirin
11. Unique international conference to focus on effectiveness, safety of medicinal herbs

Post Your Comments:

(Date:7/10/2020)... ... 09, 2020 , ... Today CJ BIO announced the first in a series ... “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across ... Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the ...
(Date:7/1/2020)... SOMERSET, N.J. (PRWEB) , ... July 01, 2020 ... ... today announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility ... with the company’s existing Japanese clinical supply facility located in Kakegawa, the new ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... software and software-driven clinical data services that accelerate drug development, is collaborating with ... an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the first ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the solution ... history of eSource, the reasons it did not take off as quickly as people ... the industry is moving towards capturing data electronically for clinical trials and then repurposing ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said ... on the market and we were pleased that the IFT jury recognized that.” reFRESH™ ... creating a natural way to extend the shelf life and improve the safety of ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most ... used to suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate ... Dr MA has been using the zebrafish model to investigate the causes of ...
(Date:7/1/2020)... , ... June 29, 2020 , ... ... to competitively procured purchasing contracts to its membership, recently named BioFit Engineered ... members with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks and ...
Breaking Biology Technology:
Cached News: