HOME >> BIOLOGY >> NEWS
Targeted Genetics presents advances in systemic gene delivery technology

--Intravenous gene delivery demonstrates efficacy in pre-clinical studies of breast cancer and head and neck cancer--

San Francisco, CA -- April 3, 2000 -- Targeted Genetics Corporation (Nasdaq: TGEN) today presented data on the company's synthetic gene delivery platform at the American Association of Cancer Research 91st Annual Meeting being held in San Francisco. Dr. Pervin Anklesaria, Senior Director of Research at Targeted Genetics, presented data indicating that the company's LPD (Lipid Polycation DNA) gene delivery system is capable of delivering genes systemically when delivered intravenously. Intravenous delivery of tgLPD-E1A, the company's second-generation cancer therapeutic, inhibited tumor growth in animal models of two different human tumors. The data were presented in an abstract titled "Systemic and Local Delivery of E1A-Cationic Lipid Complex Chemosensitizes Breast and Ovarian Cancer Cells In Vivo."

Advances in Systemic Gene Delivery Technology
In a study presented today, the LPD delivery system was used to deliver E1A, a proprietary tumor inhibitor gene, systemically to mice transplanted with human head and neck tumors. tgLPD-E1A was administered weekly beginning six days after tumor cells were transplanted into the animals. These cells express basal levels of HER-2/neu. At 13 weeks, 70 percent of the animals treated with tgLPD-E1A were tumor free, compared to only 10 percent of animals receiving either lipid alone or 5FU, and only 50 percent of animals receiving a lipoplex-E1A control.

"We have now demonstrated that intravenous delivery of tgLPD-E1A is able to inhibit tumor growth in animal models of breast and head and neck cancers," said Dr. Anklesaria. "These data show that the LPD gene delivery system may enable the systemic delivery of therapeutic genes, an important step in the evolution of gene delivery technologies. Significantly, tgLPD-E1A was seven-fold more effective at inhib
'"/>

Contact: Page Sargisson
p.sargisson@noonanrusso.com
415-677-4455 x229
Noonan/Russo Communications
2-Apr-2000


Page: 1 2 3 4

Related biology news :

1. Targeted therapy knocks out pediatric brain cancer in mice
2. Targeted therapy for lung cancer patients shows promise in extending lives
3. Targeted immunotherapy eradicates cancer in mice
4. Targeted radiation to liver tumors spares tissue, improves quality of life
5. Targeted Genetics presents data on arthritis gene therapy
6. Targeted genetics presents promising data from cystic fibrosis clinical trial
7. Targeted Genetics presents clinical data on E1A cancer gene therapy
8. Targeted Genetics presents advances in synthetic gene delivery technologies
9. Ribozyme Pharmaceuticals, Inc. Demonstrates Potent Activity Of A Ribozyme Targeted Against The Hepatitis C Virus
10. Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion
11. Marine Snail Toxin Targeted At African Toad Eggs Reveals Novel Impact On The Regulation Of Serotonin

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... , ... December 03, 2018 , ... ... Aesthetics , an emerging leader in the distribution and marketing of cutting-edge aesthetic ... growth, projecting $20MM in sales for 2018. Cartessa’s success can be attributed ...
(Date:12/5/2018)... DIEGO (PRWEB) , ... December 04, 2018 , ... ... leverage Fastec’s extensive expertise and existing IP in the development of innovative solutions ... has been integrated into diverse systems from microfluidics to industrial machinery and instrumentation, ...
(Date:11/27/2018)... ... 2018 , ... PulseEd™ uses researched technology, published in the Journal of ... flow to the penis. Regular and unimpeded blood flow to the blood vessels of ... function. The recorded results of SWT (sound wave therapy), indicated that almost 80% of ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has ... Kauai. Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a ... began traveling to the island of Kauai on an almost weekly basis to perform ...
(Date:11/13/2018)... , ... November 13, 2018 , ... , Park Systems, ... in China. With the increasingly growing demand for AFM technology in China, Park Systems ... communities by opening an office in Beijing equipped with Park AFM. , The Grand ...
(Date:11/9/2018)... ... November 08, 2018 , ... IC System, one of ... approach to increasing recovery rates by creating a comprehensive contact strategy for each ... developed by NLP Logix, a Jacksonville, Florida-based AI solutions company, and leveraged the ...
(Date:11/6/2018)... and TAHOE, Nev. (PRWEB) , ... November 06, ... ... to their native mobile app for clinical trial data collection and management. ... Now, iPhone users with compatible generation devices can quickly and easily sign in ...
Breaking Biology Technology:
Cached News: