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Targeted Genetics presents advances in systemic gene delivery technology

ize, which have enhanced stability and gene transfer efficiency. Pre-clinical experiments in non-tumor bearing mice have shown that the LPD system is able to deliver genes systemically through intravenous administration.

Background on E1A
E1A is a tumor inhibitor gene. Previous laboratory and animal studies have demonstrated E1A's ability to suppress metastases, induce apoptosis (programmed cell death) and reverse the over-expression of HER-2/neu, a cancer-causing gene. In patients with cancer, over-expression of the HER-2/neu oncogene is correlated with poor prognoses, increased tumor formation and metastasis and resistance to chemotherapeutic agents. Targeted Genetics is currently testing E1A in Phase II trials in patients with head and neck cancers and Phase I trials in patients with ovarian cancer.


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2-Apr-2000


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