The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Targeted Genetics presents data on arthritis gene therapy

AAV delivery of gene encoding ENBREL shows promise in reducing inflammation in preclinical studies

Seattle, WA-June 5, 2000-Targeted Genetics Corporation (Nasdaq:TGEN) presented data from its gene therapy program for rheumatoid arthritis (RA) this weekend at the American Society of Gene Therapy Third Annual Meeting in Denver, Colorado. The Company is utilizing its adeno-associated virus (AAV) vector technology to deliver the DNA sequence encoding tumor necrosis factor receptor-immunoglobulin Fc fusion protein (TNFR:Fc) as a treatment for RA and other inflammatory diseases. Recombinant TNFR:Fc, ENBREL (etanercept), currently marketed for the treatment of several forms of RA, was developed by Immunex Corporation. Targeted Genetics obtained rights to the gene therapy applications of numerous genes and gene delivery technologies when it was spun out of Immunex in 1992.

Dr. Haim Burstein, Senior Scientist in the Department of Research at Targeted Genetics, presented the data in an abstract titled "Treatment of Experimental Arthritis Using Recombinant AAV-TNFR:Fc Vector Gene Therapy." The studies were conducted in collaboration with Dr. Sharon M. Wahl at the National Institute of Dental and Craniofacial Research, an institute of the National Institutes of Health. In these studies, recombinant AAV vectors containing the TNFR:Fc fusion genes were evaluated in an experimental rat model of arthritis. A single intra-articular (joint) administration of AAV-rTNFR:Fc into both rear ankle joints of arthritic rats resulted in a significant reduction of ankle and hind paw swelling as measured by arthritis index scores. A single intramuscular administration produced a similar effect. Bioactive rat TNFR:Fc protein was readily detectable in the serum of treated rats 33 days after intramuscular administration of AAV-rTNFR:Fc compared to control animals.

Injection of AAV-rTNFR:Fc into a single joint led to a reduction in hind paw swelling in the c
'"/>

Contact: Page Sargisson
p.sargisson@noonanrusso.com
415-677-4455 x 229
Noonan/Russo Communications
4-Jun-2000


Page: 1 2 3

Related biology news :

1. Targeted therapy knocks out pediatric brain cancer in mice
2. Targeted therapy for lung cancer patients shows promise in extending lives
3. Targeted immunotherapy eradicates cancer in mice
4. Targeted radiation to liver tumors spares tissue, improves quality of life
5. Targeted genetics presents promising data from cystic fibrosis clinical trial
6. Targeted Genetics presents clinical data on E1A cancer gene therapy
7. Targeted Genetics presents advances in systemic gene delivery technology
8. Targeted Genetics presents advances in synthetic gene delivery technologies
9. Ribozyme Pharmaceuticals, Inc. Demonstrates Potent Activity Of A Ribozyme Targeted Against The Hepatitis C Virus
10. Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion
11. Marine Snail Toxin Targeted At African Toad Eggs Reveals Novel Impact On The Regulation Of Serotonin
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Targeted Genetics presents data arthritis gene therapy

(Date:1/8/2009)...e, NY, January 8, 2009Natural gas, believed to be ...ine airborne particulate matter when burned in hom... according to a report in the December 2008 issue ...ng Science journal, a peer-reviewed journal publi...ble free online at www.liebertpub.com/ees , I...
(Date:1/8/2009)...onal GIANT (Genetic Investigation of Anthropometri... obesity genes. So far, the scientists have analyz...sociation studies with a total of more than 32,000...es were validated in 14 further studies including ...4R genes already known, it was now possible for si...
(Date:1/7/2009)... A study published in Cancer Prevention Research ... Research, identifies components of black raspberr...s at the Ohio State Comprehensive Cancer Center fo...ack raspberries, inhibited growth and stimulated a...esophageal carcinogen. , "Our data provide stro...
(Date:1/7/2009)...machine that translates a cell,s DNA code into the...erfectionist. , Johns Hopkins researchers, repo... "proofreading step" during which the suite of tra...rors, just after making them, and definitively res... , It turns out, the Johns Hopkins researchers s...
Breaking Biology News(10 mins):Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect 2Lost in translation 2Seven Out of 10 Americans Would Vote for a Presidential Candidate Who Supports a Nationwide Health Information Network CSC Survey Says 12191 1Seven Out of 10 Americans Would Vote for a Presidential Candidate Who Supports a Nationwide Health Information Network CSC Survey Says 12191 2Seven Out of 10 Americans Would Vote for a Presidential Candidate Who Supports a Nationwide Health Information Network CSC Survey Says 12191 3Innocoll Announces Dosing of First Patient in Second US Phase 3 Clinical Trial to Investigate CollaRx 28R 29 GENTAMICIN SURGICAL IMPLANT for the Preve 1385 1Innocoll Announces Dosing of First Patient in Second US Phase 3 Clinical Trial to Investigate CollaRx 28R 29 GENTAMICIN SURGICAL IMPLANT for the Preve 1385 2Innocoll Announces Dosing of First Patient in Second US Phase 3 Clinical Trial to Investigate CollaRx 28R 29 GENTAMICIN SURGICAL IMPLANT for the Preve 1385 3Hey Boomers Heres to Your Health 21 12185 1Hey Boomers Heres to Your Health 21 12185 2Hey Boomers Heres to Your Health 21 12185 3Hey Boomers Heres to Your Health 21 12185 4Hey Boomers Heres to Your Health 21 12185 5Autism Consultant Valerie Herskowitz Retains NewsMark Public Relations to Herald the Autism Support Village and Launch of www valerieherskowitz com 12181 1Autism Consultant Valerie Herskowitz Retains NewsMark Public Relations to Herald the Autism Support Village and Launch of www valerieherskowitz com 12181 2
Other News:
...ttery and solar cell ... Toward a drug for femal...io-glue" for cornea surgery... Latest data on he...o the future malaria control spelled D-D-T... Jo...og... Mark Your Calendars Chemistry 2006San Fran...
...ist medication used for the treatment of alcoholis...ith a family history of alcoholism, suggesting a g... indicate that Asp carriers of the OPRM1 gene who ...ntrary to expectations. ......Naltrexone (NTX) is ...
...ge of Medicine of Yeshiva University have leverage...to craft a tool for unlocking the secrets of anoth...ria.... These findings, published in the August is... up research efforts to bring malaria under contro...
...ve discovered that a recently identified protein c...l mechanism to keep its repairs accurate. ... The ... group of proteins known as DNA polymerases that a...... But while other DNA-repair proteins insure the...
ACS News Service Weekly PressPac -- July 19, 2006 2ACS News Service Weekly PressPac -- July 19, 2006 3ACS News Service Weekly PressPac -- July 19, 2006 4ACS News Service Weekly PressPac -- July 19, 2006 5ACS News Service Weekly PressPac -- July 19, 2006 6ACS News Service Weekly PressPac -- July 19, 2006 7Under certain genetic circumstances, naltrexone may increase the urge to drink 2Under certain genetic circumstances, naltrexone may increase the urge to drink 3Under certain genetic circumstances, naltrexone may increase the urge to drink 4Einstein researchers find 'key' to unlocking world's deadliest malaria parasite 2Unusual mechanism keeps repair protein accurate 2Unusual mechanism keeps repair protein accurate 3
... women for operative deliveries (caesarean section... in this week's BMJ.......Researchers interviewed ...he second stage of labour at two UK hospitals betw... for operative delivery and thought that their bir...
...elopments in anaesthesia is launched in this week'...atients' concerns about anaesthesia.......David Ro... Middlesex, UK, outline how patients scheduled for...about their safety, outcome, and comfort. All medi...
... issue of THE LANCET highlight how assessment of t...ions could have potential as low-cost alternatives... children in less-developed countries. ......The c... and viral-load assessment (conventional procedure...
...umption by college students comes from self-report...restimate what is meant by "standard" drink sizes....nificantly more than they report.......Most of wha...udents comes from survey data. Yet much of what i...
health news:Potential low-cost options for monitoring HIV-1-infected children in less-developed countries 2health news:College students may be drinking more alcohol than even they realize 2health news:College students may be drinking more alcohol than even they realize 3health news:College students may be drinking more alcohol than even they realize 4
...erschow, an assistant professor of chemistry, and ...versity of Linz in Austria, have developed a compl...rs the benefits of magnetic resonance imaging (MRI...ion and setting the stage for the creation of ligh...
Who: The Food Safety Policy Center at Michigan State University......What: A news conference to release findings of a study on U.S. attitudes regarding food safety who should be responsible for it, w
... poor outcomes in the treatment of lung cancer, ac... (NSCLC) lung cancer patients who have never smoke...l rates and respond better to chemotherapy than cu...2006 issue of CANCER, a peer-reviewed journal of t...
WINSTON-SALEM, N.C. Their experience treating a rare type of abdominal cancer has helped physicians at Wake Forest University Baptist Medical Center make a new discovery that may change the way it is
health news:NYU, Austrian researchers create non-invasive imaging method with advantages over conventional MRI 2health news:Non-smokers with lung cancer respond better to treatment than smokers, study says 2health news:Doctors learn more about diagnosing rare form of cancer 2health news:Doctors learn more about diagnosing rare form of cancer 3