HOME >> BIOLOGY >> NEWS
Tau Gene Linked To Family Of Neurodegenerative Disorders; Finding May Yield Insight Into Onset Of Alzheimer's Disease

Researchers led by a UC San Francisco neurologist are reporting findings that they say may put them an important step closer to understanding the way in which Alzheimer's disease ravages the brain cells of patients.

In a paper published in the October 27 issue of Proceedings of the National Academy of Sciences, the researchers announce that they have identified three mutations in a gene that produces the tau protein, and have determined that these mutations cause several related hereditary neurodegenerative diseases, the most prevalent known as frontotemporal lobe dementia.

While the finding does not directly implicate the tau gene in Alzheimer's disease, it does so strongly by association, said the senior author of the study, Kirk Wilhelmsen, MD, an assistant professor neurology at UCSF. The tau protein has long been a suspected factor in Alzheimer's disease because abnormal, insoluble, tangled filaments of the protein-are always found in the autopsied brains of people who have the disease. But because researchers have never found a mutation in the tau gene of Alzheimer's patients, they had come to think that the neurofibrillary tangles, composed primarily of tau protein, were but an inconsequential by-product of some other factor that actually caused nerve cell degeneration.

Now that there is hard evidence that tau, itself, is capable of killing brain cells, the picture changes, said Wilhelmsen. "Finding a direct link between mutations in the tau gene and these hereditary neurodegenerative diseases strongly indicates that tau is an important player in neurons dying in Alzheimer's disease and many other diseases, as well," he said.

The goal now, he said, is to figure out what causes tau protein to accumulate in insoluble filaments in the brain cells of Alzheimer's patients. While mutations in tau gene appear to lead directly to cell death in the hereditary diseases studied, Wilhelmsen said he and colleagues don't believe that a tau mutation oc
'"/>

Contact: Jennifer O'Brien
jobrien@itsa.ucsf.edu
415-476-2557
University of California - San Francisco
27-Oct-1998


Page: 1 2 3 4

Related biology news :

1. Alzheimers Disease And Developmental Biology Linked Through Single Molecule
2. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy
3. Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer
4. Genetic Mutations Linked To Rare Metabolic Disease
5. In The Genes: Extra Belly Fat, Insulin Resistance Linked
6. Familial Cancer Syndrome Linked to Colorectal Cancer in Younger People
7. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
8. Elevated Blood Levels Of Inactive TPA Linked To Increased Stroke Risk In Young Women
9. Clues To Transplant Tolerance Linked To Infectious Disease Immunity Cell Traffic Key, Say Authors In New England Journal of Medicine
10. Memory Loss In Old Age No Longer Linked To Dying Brain Cells
11. Inherited Depression Linked To Shortage Of Cells In Brain Region

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... ... 04, 2018 , ... Urological Associates of Southern Arizona today ... Excellence. The designation recognizes that Dr. Choi has achieved a high level of ... care for men suffering from symptoms associated with Benign Prostatic Hyperplasia or BPH. ...
(Date:11/29/2018)... (PRWEB) , ... November 29, 2018 , ... ... in Semba Biosciences with the intention of acquiring full ownership. The transaction was ... Agreement was executed on November 14, 2018. “We are extremely pleased to team ...
(Date:11/27/2018)... ... November 27, 2018 , ... LabArchives ... worked together to integrate the LabArchives Classroom Edition with Current Protocols Essential Laboratory ... be available beginning January of 2019. , The integration of LabArchives ...
Breaking Biology News(10 mins):
(Date:12/5/2018)... ... 2018 , ... The incredible life story of former refugee and LG Sonic ... Carlos Moedas, the European Commissioner for Research and Innovation. , In his November ... Commissioner Moedas spoke at length of Yousef’s life and journey, citing the man who ...
(Date:11/28/2018)... ... 28, 2018 , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi Abel ... height of truffle season. , Her first stop was Umbria, a region ... exclusive Black Truffle Lodge in the small mountain village of Pettino, Chef Jodi was ...
(Date:11/20/2018)... SPRINGS, Ga. (PRWEB) , ... November 19, 2018 , ... ... now receive custom dental implants from Dr. Dan Myers at THE DENTIST ... offering dental implant placement and restorations for the last 20 years. He now offers ...
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. Patrick Leadbeater, has begun ... Dr. Leadbeater, of Kahala Pet Hospital on Oahu, is a skilled ... traveling to the island of Kauai on an almost weekly basis to perform surgery ...
Breaking Biology Technology:
Cached News: