HOME >> BIOLOGY >> NEWS
Team Of Max Planck Scientists Elucidates Structure Of A Protein Segment Involved In 'Von Recklinghausen Neurofibromatosis'

Scientists at the Max Planck Institute for Molecular Physiology in Dortmund and of the Max Planck Institute for Medical Research in Heidelberg (Germany) have determined the first structure of a functional protein unit that is involved in the development of ‘von Recklinghausen neurofibromatosis’. This unit is a regulator of another protein involved in the pathogenesis of numerous tumors, linking neurofibromatosis to tumor development. The work, published in the August 3, 1998, issue of EMBO Journal, confirms mechanistic ideas about the function of this protein stemming from the authors' fundamental structural and biochemical studies of the related protein p120GAP (Mittal et al., 1996, Science 273, 115-117; Scheffzek et al., 1996, Nature 384, 591-596; Scheffzek et al., 1997, Science 277, 333-338; Ahmadian et al., 1997, Nature Struct. Biol. 4, 686-689).

von Recklinghausen neurofibromatosis, also called type 1 neurofibromatosis or simply NF1, is an inherited disease that predisposes the formation of certain types of tumors and may be associated with a number of other symptoms including learning disabilities and mental retardation. So-called Lish nodules of the iris or pigmentation abnormalities of the skin (so-called ‘caf-au-lait spots’) and neurofibromas, benign cutaneous tumors, are hallmarks of NF1 with important diagnostic relevance. In rare cases, NF1 may develop into malignant tumors.

The so-called NF1 gene is responsible for the development of the disease. It codes a huge protein, termed neurofibromin, comprising nearly 3000 amino acids, and it is disrupted or mutated in patients affected with
'"/>

Contact: Klaus Scheffzek
Klaus.Scheffzek@mpi-dortmund.mpg.de
Fax: 49-231-1206-23
Max-Planck-Gesellschaft
14-Aug-1998


Page: 1 2 3 4

Related biology news :

1. 2004 Max Planck Research Prize for Martin Vingron and Eugene W. Myers
2. Max Planck Research awards 2003 presented
3. Max Planck supports open access to research
4. Two Max Planck researchers recieve the Louis-Jeantet Prize for Medicine 2003
5. Max-Planck doctoral student discovers living fossils
6. One Way Traffic: Max Planck Scientists Idendified Genes Involved In Transporting An Important Plant Growth Factor
7. Max Planck Scientists Report Molecular Details On The Interaction Of The Stress Hormone Corticotropin-Releasing Factor (CRF) And Its Receptor
8. Towards A Local Stimulation Of Natural Bypass Growth - Max Planck Scientists Developed New Treatment For Ischemic Heart Disease
9. Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme
10. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
11. Scientists sequence genome of kind of organism central to biospheres carbon cycle

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: