HOME >> BIOLOGY >> NEWS
Team Solves X-ray Structure Of Powerful Enzyme

MADISON, Wis. -- Researchers at the University of Wisconsin Medical School and the National Institutes of Health have determined the three dimensional molecular structure of a powerful enzyme responsible for activating many cell functions.

Reported in the current issue of the journal Cell, the new information is a crucial step in the potential development of drugs that may be used to control unchecked cell growth leading to cancer as well as the spread of cancer throughout the body.

The research represents a milestone in an on-going UW Medical School effort to fully understand the large family of enzymes known as phosphoinositide kinases. The enzymes are usually located on the cell membrane, where they receive signals from outside the cell. They relay the signals by generating "second messengers," which in turn pass them along to proteins that initiate and control various kinds of cellular activity.

"The enzymes regulate a cascade of events related to almost every aspect of cell function in our bodies, including the ability of cells to move and secrete neurotransmitters and hormones, and their ability to divide and grow," said UW Medical School professor of pharmacology Richard Anderson, who directed the research. "When the second-messenger signalling system doesn't function properly, cells can proliferate wildly, causing cancers, or travel to distant parts of the body, resulting in cancer metastasis."

UW Medical School's pharmacology department has a deep and long-running interest in phosphoinositide kinases. More than 50 years ago Dr. Lowell Hokin was the first to discover the enzymes and the signalling cascade they initiate in cells. Following this tradition, scientists in Anderson's laboratory were the first to isolate the gene underlying these enzymes, and to purify them and define their biochemical composition.

For the current Cell (Sept. 18) study, the Anderson team genetically engineered bacterial cells to produce large quantities
'"/>

Contact: Dian Land
dianland@macc.wisc.edu
(608) 263-9893
University of Wisconsin-Madison
28-Sep-1998


Page: 1 2

Related biology news :

1. Biochemist Solves Riddle Of Collagen Stability
2. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
3. New X-ray sources speed protein crystallography
4. Digital X-ray microtomography yields stunning views of limb regeneration
5. X-ray analysis of shipwreck may help conservators save waterlogged artifacts
6. Researchers at Vanderbilts Free-Electron Laser Center are developing new forms of laser surgery, improved X-ray technology, and better methods for protein identification
7. X-ray crystallography at Advanced Photon Source
8. X-ray studies shed light on frog deformities
9. X-rays may show way to better Alzheimers drugs
10. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
11. Structure solved by Scripps scientists shows one way that body controls gene expression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... ... April 30, 2020 , ... Flagship ... Corritori Consulting Inc., a biopharmaceutical and regulatory services advisor. The companies now deliver ... Flagship and Corritori are taking a collaborative approach to empower more confident and ...
(Date:4/30/2020)... ... 2020 , ... At the start of 2020 ILC ... a wide range of industries including pharmaceutical and biopharmaceutical manufacturing, healthcare, food and ... decade, it was clear to company leadership that they would have to adapt ...
(Date:4/22/2020)... ... ... RCH Solutions (RCH ), a global provider of Bio-IT computing expertise ... Wlodarczyk as Director of Sales and Business Development. Based out of RCH’s location in ... presence across the Northeast. , “We continue to see increased demand for specialized scientific ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... , ... May 05, 2020 , ... ProductLife Group ... high-profile CEO. Xavier Duburcq joins the group after 13 years at Altran, where he ... Holding a PhD in Immunology and being a Pharmacist, Xavier was involved in his ...
(Date:4/23/2020)... (PRWEB) , ... April 22, 2020 , ... ... equipment for healthcare providers to protect themselves from COVID-19. Virginia has only been ... the Federal Emergency Management Association (FEMA). , As Governor Northam told the Virginia ...
(Date:4/18/2020)... ... April 17, 2020 , ... ... Small Business Innovation Research (SBIR) program to support the expansion of its digital ... the NSF, which conducts a rigorous merit-based review process, adds to NeuroFlow’s ...
(Date:4/1/2020)... ... March 30, 2020 , ... A joint ... Diagnostics (RID), formed earlier this year to bring telehealth to various government agencies, ... for COVID-19. Company officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from ...
Breaking Biology Technology:
Cached News: