Team Solves X-ray Structure Of Powerful Enzyme

of one member of the enzyme family exactly as it is found in its natural state. The large, accurate quantities were required for collaborator James Hurley of the NIH to determine the three-dimensional X-ray crystal structure of the enzyme. The technique entails growing a crystal of the enzyme, taking an X-ray picture of it and then processing the X-ray image through a computer.

"Understanding the structure of the enzyme at the molecular level, as we have done with this X-ray crystallography, will help scientists figure out how to manipulate it," said Anderson. "Using these studies as a foundation, we will be able to modify the enzyme, either genetically or by developing therapeutic drugs that can block the generation of second messengers."

Anderson said the next step for his laboratory will be to use the structural information to study the way the enzymes control activities that result in functions such as cell growth and movement.


Contact: Dian Land
(608) 263-9893
University of Wisconsin-Madison

Page: 1 2

Related biology news :

1. Biochemist Solves Riddle Of Collagen Stability
2. Many physicians misperceive radiation risks to developing fetuses from X-rays and CT scans
3. New X-ray sources speed protein crystallography
4. Digital X-ray microtomography yields stunning views of limb regeneration
5. X-ray analysis of shipwreck may help conservators save waterlogged artifacts
6. Researchers at Vanderbilts Free-Electron Laser Center are developing new forms of laser surgery, improved X-ray technology, and better methods for protein identification
7. X-ray crystallography at Advanced Photon Source
8. X-ray studies shed light on frog deformities
9. X-rays may show way to better Alzheimers drugs
10. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
11. Structure solved by Scripps scientists shows one way that body controls gene expression

Post Your Comments:

(Date:5/30/2020)... , ... May 29, 2020 , ... ... digital transformation for enterprises globally, has collaborated with EchoNous Inc. to develop the ... It can measure systolic heart function, which has been clinically tested versus expert ...
(Date:5/28/2020)... ... May 28, 2020 , ... Actuate Therapeutics, ... their 1801 Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be presented at ... place virtually on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s principal investigator ...
(Date:5/21/2020)... (PRWEB) , ... May 19, ... ... the leading software-as-a-service (SaaS) provider of operations management solutions, today introduced BioMed ... module provides a cloud-based platform for connecting the people and systems around ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
(Date:6/28/2020)... ... June 26, 2020 , ... ... solutions providers, today announced its strong opposition to the recently introduced bicameral ... a blanket ban on most federal use of nearly all biometric and related ...
(Date:6/23/2020)... , ... June 22, 2020 , ... ... glutamine antagonist, DRP-104, will be presented June 22-24 during the American Association for ... DRP-104; and, the other profiles the potent, consistent single agent activity in KEAP1 ...
(Date:6/11/2020)... ... June 09, 2020 , ... ... of a Small Business Innovation Research (SBIR) program funded by the National Institute ... Toxin Detection in the Field”. The project’s goal was to engineer and develop ...
Breaking Biology Technology:
Cached News: