HOME >> BIOLOGY >> NEWS
Technique brings immune-based therapies closer to reality

Johns Hopkins researchers have developed an inexpensive, reliable way to make large quantities of targeted immune cells that one day may provide a life-saving defense against cancers and viral infections.

Using artificial antigen presenting cells, or aAPCs, the scientists converted run-of-the-mill immune cells into a horde of specific, targeted invader-fighting machines, they report in the advance online version of Nature Medicine on April 21.

"The ability to make vast quantities of targeted, antigen-specific immune cells in the lab broadens their potential in tackling a wide array of diseases, especially cancers," says Jonathan Schneck, Ph.D., professor of pathology and medicine at the Johns Hopkins School of Medicine. "Our technique provides an off-the-shelf way to create these cells."

The immune system normally defends the body against invaders. However, in cancer, tumor cells aren't recognized as "foreign," and after bone marrow and organ transplant the immune system has to be suppressed to avoid rejection of the transplant, opening the door to viral infections. Specially targeted immune cells that fill these defensive gaps are already being tested as experimental "cancer vaccines" in patients with melanoma and multiple myeloma and as virus fighters after bone marrow transplant.

However, the technological advance reported by the Johns Hopkins team overcomes a major weakness of current methods for making these targeted immune cells, known as antigen-specific cytotoxic T cells (CTLs) -- namely the methods' reliance on a patient's own dendritic cells. Dendritic cells are immune system sentries that wave the proteins, or antigens, of foreign invaders like flags, teaching immune system T cells to recognize the invading cells and kill them.

"But dendritic cells vary in quality and number from patient to patient," says first author Mathias Oelke, Ph.D., a postdoctoral fellow in pathology at Johns Hopkins. "Man
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
22-Apr-2003


Page: 1 2 3

Related biology news :

1. Nerve cells guided to repair spinal damage: Technique
2. Technique plucks rapidly evolving genes from a pathogens genome
3. Technique kills cancerous cells, leaves healthy cells intact
4. Technique may identify novel disease genes at a faster clip
5. Technique to induce cancer cells to commit suicide developed by Hebrew University scientists
6. UF Anthropologists Study Techniques To Solve Mysteries Of Dead Bodies
7. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
8. Researchers Uncover 3-D Structure Of Virus Replication Technique
9. UF Researcher: New Techniques Help Reconstruct Ancient Diets
10. Technique Measures Muscle Contraction At Molecular Level
11. New Monitoring Technique Checks Thyroid Cancer Without Misery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® Inc., ... have opened a Customer Experience Center (CEC) and office in Munich, Germany. Rapid ... , The Munich CEC will be a place for researchers throughout Europe to ...
(Date:8/14/2019)... ... 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week will ... “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” said ... to explain that as a part of Biotech Week Boston – the annual biotech ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... of Molecular Pathology, Institute of Cancer Research (ICR) in a live webinar ... about the process of biomarker and companion diagnostic development including machine learning approaches ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), ... to the FDA for use of a person’s own adipose-derived stem cells to treat ... in the knee. This IND is the first of several planned clinical trials ...
(Date:6/11/2019)... (PRWEB) , ... June 10, 2019 , ... ... science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your ... Eppendorf Group) and will educate viewers about how its technology facilitates laboratories to ...
(Date:6/11/2019)... ... 11, 2019 , ... Veterinary Regenerative Medicine company, VetStem ... announced that their GMP facility for cell production is now approved by the ... is an important milestone for VetStem as it expands into contract cell manufacturing ...
Breaking Biology Technology:
Cached News: