HOME >> BIOLOGY >> NEWS
Technique plucks rapidly evolving genes from a pathogen's genome

do it with just a single genome sequence, instead of lining up genes from different genomes and comparing sequences."

Fraser works in the laboratory of Michael Eisen, a UC Berkeley adjunct assistant professor of molecular and cell biology and a member of the QB3 consortium (California Institute for Quantitative Biomedical Research).

"This technique can be used to quickly identify pathogenic genes that interact closely with the human immune system, since these genes are under tremendous pressure to evolve quickly," said coauthor Joshua B. Plotkin, a junior fellow in the Faculty of Arts and Sciences at Harvard. "Such genes are prime targets for new drugs and vaccines to counter deadly pathogens."

The technique involves a statistical analysis of an entire genome, comparing the rate of change of a specific gene to the average rate of change within the genome. An organism's genome is a sequence of DNA nucleotides - either A, G, T or C (for adenine, guanine, thymine and cytosine) - grouped into triplets, called codons. Each codon codes for a specific amino acid to be strung together to create a protein. The series thymine, cytosine and adenine - a TCA codon - always yields a serine amino acid, for example.

Because 64 DNA triplets can be made from the four available DNA nucleotides but there are only 20 different amino acids, some amino acids are coded by more than one codon. Arginine, for example, is coded by six different codons: CGA, CGC, CGG, CGT, AGA and AGG.

Based on an idea by Plotkin, the team zeroed in on the susceptibility of codons to point mutations - alteration of a single DNA nucleotide - and the fact that not all point mutations have the same effect. A random point mutation in some codons is less likely to create a codon that codes for a different amino acid. For example, the conversion of CGA to CGC would still result in an arginine, leaving the protein's amino acid sequence unchanged. Based on the structure of the g
'"/>

Contact: Robert Sanders
rls@pa.urel.berkeley.edu
510-643-6998
University of California - Berkeley
29-Apr-2004


Page: 1 2 3 4

Related biology news :

1. Nerve cells guided to repair spinal damage: Technique
2. Technique kills cancerous cells, leaves healthy cells intact
3. Technique may identify novel disease genes at a faster clip
4. Technique brings immune-based therapies closer to reality
5. Technique to induce cancer cells to commit suicide developed by Hebrew University scientists
6. UF Anthropologists Study Techniques To Solve Mysteries Of Dead Bodies
7. Penn Researchers Develop Gene Therapy Technique That Reverses Muscle Membrane Weakness In Muscular Dystrophy Variant
8. Researchers Uncover 3-D Structure Of Virus Replication Technique
9. UF Researcher: New Techniques Help Reconstruct Ancient Diets
10. Technique Measures Muscle Contraction At Molecular Level
11. New Monitoring Technique Checks Thyroid Cancer Without Misery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, ... need a comparability study, but what is the most effective way to complete ...
(Date:7/2/2020)... ... July 01, 2020 , ... ... 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host ... by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... 01, 2020 , ... Slone Partners , a nationwide ... placement of Julianne Averill , CPA, as Chief Financial Officer at ... implementing key business strategies to accelerate Alveo’s growth as the company advances its ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... available for free its new white paper – Simulated Transport Methodologies. Regulatory ... today’s biologics licensing application (BLA). In response, Modality Solutions shares an explanation ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now offering patients ... million stem cells total, patients may choose which extremities they would like treated. , ... (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained from a ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
Breaking Biology Technology:
Cached News: