HOME >> BIOLOGY >> NEWS
Test method provides biocompatibility 'barometer'

A new method for quantitatively measuring the compatibility of materials with living tissues has been developed by researchers at the National Institute of Standards and Technology (NIST). Described in a Dec. 11 presentation at the Tissue Engineering Society International's conference in Orlando, Fla., the technique should provide a more sensitive and reliable means to evaluate the biocompatibility of new materials for a wide range of applications from contact lenses to dental coatings to bone implants.

A paper outlining the new method has been accepted for publication in the Journal of Biomedical Materials Research.

The new method, which represents a novel application of existing bench-top scientific instruments, is a two-step process. The first step involves using a device called a polymerase chain reaction instrument to measure the levels of an organism's cytokines when exposed to a given material. Cytokines are signaling molecules released by white blood cells to protect the body from foreign materials. Higher levels of cytokine production generally indicate non-biocompatible materials have caused inflammation. The second step involves testing exposed cells for a specific protein in the cell membrane, the presence of which indicates cells are dying. This is a complementary test for more serious responses to materials because dying cells are often not capable of producing cytokines. The NIST tests were conducted on cultured mouse cells, which produce similar responses as whole tissues.

NIST post-doctoral researcher LeeAnn Bailey called the new method a "barometer" of biocompatibility.

Whereas current means to test biocompatibility produce a yes/no result that a material is minimally biocompatible or not, the new analysis can tell which materials are more biocompatible than others. Industry and researchers should be able to use this method to produce new materials for dentistry and other medical applications that are even more well
'"/>

Contact: Scott Nance
scott.nance@nist.gov
301-975-5226
National Institute of Standards and Technology (NIST)
19-Dec-2003


Page: 1 2

Related biology news :

1. OHSU researchers discover possible method for early detection, prevention of premature birth
2. Japanese researchers develop novel method of introducing transgenes into animals
3. New screening method turns up potential compound for treating anthrax
4. Radiologists provide safe delivery method for gene therapy
5. New method is first to mimic subtle genetic changes
6. New method for determining age of artifacts fills chronological gap for scientists
7. Proven method of bone analysis may clarify human origins
8. UVa researchers describe method of protecting chromosomes during cell division
9. Computer method identifies potentially active enzymes
10. Risk and food are on the same plate: World food safety experts offer new methods to assess risk
11. Purdue engineers develop quick, inexpensive method to prototype microchips

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Test method provides biocompatibility barometer

(Date:10/15/2014)... resistance to bacterial pneumonia in female mice to an ... Females are naturally more resistant to respiratory infections than ... that increased resistance to bacterial pneumonia in female mice ... (NOS3). They also show that this enzyme is ultimately ... estrogen. , The team, lead by Professor Lester Kobzik ...
(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
(Date:10/14/2014)... 14, 2014 – High doses of fish oil supplements, rich ... common type of irregular heartbeat in which the heart can ... of the AFFORD trial led by the Montreal Heart Institute ... of Cardiology on October 7th. , For the trial, ... were randomly assigned to 4 grams of fish oil a ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/20/2014)... VIENNA , October 20, 2014 ... of gastrointestinal (GI) disorders and the delivery of care ... liver diseases and worrying inequalities in the provision of ... survey, which was commissioned by United European Gastroenterology (UEG), ... greater political and public awareness of the burden of ...
(Date:10/20/2014)... OncLive® is pleased to ... Thomas Jefferson University has joined its Strategic Alliance ... Partnership program, the Sidney Kimmel Cancer Center at ... of the Center’s cutting-edge research programs, comprehensive approach ... other health care professionals from the Sidney Kimmel ...
(Date:10/19/2014)... The Latin American hardware encryption display ... America with analysis and forecast of revenue. This market ... expected to reach $2,366.8 million by 2018, at a ... through the TOC of the Latin American hardware encryption ... analysis provided. It also provides a glimpse of the ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
Breaking Biology Technology:Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
Cached News: