The APCs of autoimmune disease( Automimmune diseases are a complex set ...)

Automimmune diseases are a complex set of disorders that all result from a failure of the immune system to recognize "self" due to the presence of autoreactive T cells. The body has several means of removing autoreactive T cells, including T cell deletion in the thymus and peripheral tolerance for T cells that escape thymic deletion. These mechanisms, however, fail in some individuals, resulting in an autoimmune response that can be crippling. Many of the factors, both environmental and genetic, involved in autoimmune disease development remain a mystery. Vijay Kuchroo and colleagues of Brigham and Woman's Hospital and Harvard Medical School used autoreactive transgenic T cells in an experimental autoimmune encephalomyelitis (EAE)resistant mouse strain and now present data showing that the activation state of APCs plays a role in the development of autoimmune diseases (pages 990997). T cell number and response were the same in both the transgenic EAE-resistant and EAE-sensitive backgrounds; however, the APCs in the EAE-resistant background had a lower activation state and lower T cell stimulating response than those in the EAE-sensitive strain. Furthermore, innate immune receptor activation of the APCs resulted in EAE development even in the resistant background, providing insight into why viral infection is often associated with the onset of certain autoimmune disorders.

'"/>

Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
2-Apr-2004

Page: 1
Related biology news :

1. Long-term effects of carbon monoxide poisoning are an autoimmune reaction
2. Protein may reduce susceptibility to autoimmune disease
3. New research suggests therapeutic approach for autoimmune diseases
4. Protein may help prevent autoimmune attacks
5. A multi-institutional study may offer clues for the treatment of some autoimmune diseases
6. Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases
7. A new mechanism that triggers autoimmune disease
8. Yale researchers shed light on B cells involvement in autoimmune diseases like lupus
9. Researchers identify gene involved in autoimmune disease
10. Collaboration advances potential therapy for autoimmune diseases
11. Study finds autoimmune link in juvenile Batten disease