HOME >> BIOLOGY >> NEWS
The Best Molecular Snapshot Yet Of Cells Affected By Alzheimer's Disease

While the dementia and agitation of Alzheimer's disease are painfully obvious to care-givers, the roots of the disease lie hidden and unknown deep in the brains of patients. Now a University of Rochester team has developed a technology that sheds light on the disease at its origins, in the nerve cells throughout the brain that sicken and die.

The team has taken the sharpest molecular snapshots yet of cells affected by the disease, simultaneously measuring the activity of 20 genes within those cells. Scientists believe these profiles of individual cells provide the most thorough information yet on cells from the brains of deceased Alzheimer's patients and provide a way to compare healthy and sick cells in unprecedented detail. The work is reported in the August 4 issue of the Proceedings of the National Academy of Sciences.

"Many Alzheimer's researchers are looking for a molecular change in the blood, or in the spinal fluid, but that's like looking for a needle in a haystack," says Zaven Khachaturian, director of the Alzheimer Association's Ronald and Nancy Reagan Institute and former director of Alzheimer's disease research at the National Institutes of Health. "The Rochester team is able to focus in on cells that actually show pathology from the disease and can compare those to cells that show no sign of disease. That is a significant starting point toward understanding what is happening much, much earlier in the brains of people who have this disease. It's no longer a hit-and-miss approach.

"There is good reason to be excited about this technology."

In Alzheimer's disease, nerve cells throughout the brain die -- but not all cells, not even all the cells in any given neighborhood. Healthy and sick cells are interspersed in the brains of the 4 million people in the United States who have the disease, the leading cause of dementia in the elderly.

"Most researchers take a piece of tissue -- which includes sick neurons,
'"/>

Contact: Tom Rickey
trickey@admin.rochester.edu
716-275-7954
University of Rochester
3-Aug-1998


Page: 1 2 3 4

Related biology news :

1. Molecular motor implicated in tissue remodeling
2. 16th EORTC NCI AACR Symposium Molecular Targets and Cancer Therapeutics
3. 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
4. Molecular staples shape a cancer killer
5. Molecular motor myosin VI moves hand over hand, researchers say
6. Molecular therapeutics advance fight against brain cancer
7. Molecular motor shuttles key protein in response to light
8. Molecular traffic cop directs cellular signals
9. Molecular marker predicts success of breast cancer treatment
10. Molecular image of genotoxin reveals how bacteria damage human DNA
11. Molecular mechanism found that may improve ability of stem cells to fight disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2018)... ... July 31, 2018 , ... GSL Biotech ... with LabArchives , the leading cloud-based Electronic Lab Notebook (ELN) platform. , ... researchers to store all of their research data records in a secure, compliant online ...
(Date:7/29/2018)... ... 29, 2018 , ... Dr. William Plikerd, an evidence-based energy healer, today announces ... immunity and to combat inflammation and autoimmune disorders. , The preclinical research assessed ... reported:, Up to 260% increase overall immunity as seen ...
(Date:7/26/2018)... ... July 25, 2018 , ... Boston Biotech Conferences will ... 4, 2018 at The Hilton Boston Back Bay Hotel. This peer-to-peer meeting provides ... and dissect the most relevant deals in biotech. , George Golumbeski recently joined ...
Breaking Biology News(10 mins):
(Date:8/7/2018)... ... August 06, 2018 , ... Slone Partners, ... the placement of Dr. Paul Harney as President, North America at Prescient Healthcare ... and enhancing client satisfaction. He was also named to Prescient’s Board of Directors. ...
(Date:7/31/2018)... ... July 31, 2018 , ... ... years, announces the launch of their new website. The new website has been ... the site. Mahoney partnered with Proceed Innovative to build a website created for ...
(Date:7/25/2018)... ... July 25, 2018 , ... Vium, Inc. ... Digital Vivariumâ„¢ and Vium Cloud approach to accelerate preclinical drug discovery and development, ... the company announced the appointment of Jeff Caron to the newly formed role ...
(Date:7/24/2018)... ... July 24, 2018 , ... R3 Stem Cell is now offering regenerative therapies ... offered by Double Board Certified providers, with outcomes significantly improving patient quality of life. ... have done nothing to help repair and regenerate damaged lung tissues. Stem cell ...
Breaking Biology Technology:
Cached News: