HOME >> BIOLOGY >> NEWS
The Chemical Leupeptin Protects Against Noise-Induced Hearing Loss In Animal Model, UB Hearing Researchers Show

BUFFALO, N.Y. -- Researchers in the University at Buffalo Center for Hearing and Deafness have shown for the first time that a compound called leupeptin may help protect against the noise-induced hearing loss caused by living in noisy industrialized societies.

Using an animal model, researchers found that treating the inner ear with leupeptin before exposure to high-level noise, comparable to a jet engine, reduced the loss of sensory hair cells by 60 percent. Hair cells convert sound waves into electrical impulses that are sent to the brain.

Leupeptin, however, did not protect against the damaging effects of the anti-cancer drug carboplatin that can cause deafness in treated patients.

Results of the study, lead by Richard J. Salvi, Ph.D., professor of communicative disorders and sciences in UB's College of Arts and Sciences and co-director of the center, appear in the current issue (Vol. 10, No. 4) of NeuroReport.

"The results are very exciting for two reasons," Salvi said. "First, they provide clues to the cellular events that lead to sensory-cell death in the inner ear. Second, they suggest a potential drug-therapy approach to protecting the ear against sound damage."

Salvi and his colleagues at UB and his collaborators, Alfred Stracher, Ph.D., and Abraham Shulman, Ph.D., both at the SUNY Health Science Center at Brooklyn, have been investigating ways to protect the auditory system from damage via noise and ototoxic drugs, common causes of deafness in Western societies.

This study was based on the knowledge that, in many cases, degeneration of nerve function is caused by a cascade of events, beginning with a trauma that induces an increase of calcium in nerve cells. Excess calcium, in turn, increases the level of enzymes called calpains, which promote the breakdown of proteins and other factors critical to nerve functioning.

"Drugs tha
'"/>

Contact: Lois Baker
ljbaker@ buffalo.edu
716-645-2626
University at Buffalo
9-Apr-1999


Page: 1 2

Related biology news :

1. Chemical engineering grad students will take notable national awards
2. Chemical derived from vitamin-E shows early promise as cancer drug
3. Chemical genetics identifies SARS inhibitors
4. Chemical signals health of brain cells Symposium
5. Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
6. Chemical engineers discover filtration system to help biotech industry
7. NIH roadmap for biomedical research focus of chemists at American Chemical Society meeting
8. American Chemical Society media registration
9. Chemical Society announces EPA awards for environmentally friendly technology
10. NIH launches first center in Nationwide Chemical Genomics Network
11. Chemical reaction in birds provides sense of direction during migratory flights

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/22/2019)... ... 21, 2019 , ... The inventors of a new and ... major step forward with that therapy, known as SurVaxM. MimiVax LLC principals Robert ... from Roswell Park in 2012, has entered into a China-exclusive licensing agreement for ...
(Date:11/19/2019)... ... November 19, 2019 , ... Project Lifeline – ... Stores (NACDS) Foundation to address substance use disorder (SUD) – will take ... who have led to the program’s effectiveness in preventing and treating opioid abuse in ...
(Date:11/19/2019)... ... , ... The inaugural Cell & Gene Therapy Day takes place February 27, ... will be chaired by Dr Aiman Shalabi, VP R&D, Cell and Gene Therapies for ... witnessing significant innovation in cell and gene therapies, and we are at a turning ...
Breaking Biology News(10 mins):
(Date:11/6/2019)... ... November 06, 2019 , ... LeadingBiotech ,?an exclusive ... announces its East/West CEO conference to be held January 11-12, 2020 ... Kicking off the week of the J.P. Morgan Healthcare Conference and other biotech ...
(Date:11/5/2019)... ... November 05, 2019 , ... ... it has received CE Mark for its Fusion Bx 2.0 prostate fusion biopsy ... user-friendly interface, the Fusion Bx 2.0 will give urologists across Europe the ability ...
(Date:11/2/2019)... TORONTO (PRWEB) , ... October 31, 2019 , ... ... are not always used to communicating with each other: study managers, principal investigators, ... cause misunderstandings if a party is not informed of the latest data, potentially ...
(Date:11/2/2019)... ... October 31, 2019 , ... ... pharma artificial intelligence pioneer tellic. drug360 brings tellic’s expertise in biomedical language ... allows researchers to quickly uncover relationships between genes, diseases, variants, phenotypes, and other ...
Breaking Biology Technology:
Cached News: