HOME >> BIOLOGY >> NEWS
The HIV Nef protein plays both offense and defense in the battle between the AIDS virus and the body's immune system

In fighting the body's immune system, HIV owes part of its success to its ability to destroy those cells normally recruited to mount the body's counter-attack against the HIV-infected cells. Lying at the crux of such success is a viral protein called Nef, which protects its infected host while simultaneously destroying the neighboring uninfected cells of the immune system, according to scientists at the Gladstone Institute of Virology and Immunology.

"It's HIV going both ways, playing offense and defense," said Warner C. Greene, MD, PhD, director of the Gladstone Institute of Virology and Immunology and UCSF professor in the departments of medicine and microbiology and immunology. "It is a rather remarkable example of the cunning strategy the AIDS virus employs to help ensure its survival and spread."

Researchers have long known that cells surrounding an HIV-infected cell are eliminated by way of a programmed self-destructive process known as apoptosis. And Nef, the researchers knew, somehow plays a key role in triggering this destruction. Now in a study published in the April 12, 2001 issue of Nature, Gladstone scientists have discovered that Nef also protects its infected host cell from the detrimental effects by using the same trigger. The new study shows that Nef does this by binding to and inhibiting a protein called ASK1, a key player in apoptosis.

"If we could effectively block the assembly of Nef and ASK1, it could lead to the premature death of the HIV-infected host cell," Greene said. "The HIV infection process would then be short-circuited and the virus might simply die out because it would not have sufficient time to fully reproduce itself."

Achieving such a block will require discovering and developing a molecule that interrupts the assembly of Nef and ASK1, helping to "tip the balance in favor of the body effectively dealing with the virus," he said.

Identifying such a molecule could lead to the develop
'"/>

Contact: Laura Lane
llane@gladstone.ucsf.edu
415-476-2557
University of California - San Francisco
10-Apr-2001


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... 20, 2017 At this year,s CeBIT Chancellor Dr. ... manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together with the ... year,s CeBIT partner country. At the largest German biometrics company the two ... face and iris recognition as well as DERMALOGĀ“s multi-biometrics system.   ... ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric ... ... DERMALOGs Face Matching enables to match face pictures ... the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face ...
(Date:3/7/2017)... Brandwatch , the leading social intelligence company, today announces that ... uncover insights to support its reporting, help direct future campaigns, and ... youth charity will be using Brandwatch Analytics social listening and analytics ... of the topics and issues that are a priority for its ... "Until recently ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 2017 NetworkNewsWire Editorial Coverage  ... Cancer remains one ... on health care systems, in terms of costs and resources. ... does the development of innovative and efficient therapies that demonstrate ... many types of cancer treatments, a growing number of patients ...
(Date:3/22/2017)... TARRYTOWN, N.Y. , March 22, 2017 Regeneron ... among the Regeneron Genetics Center (RGC), U.K. Biobank and GSK ... in the U.K. Biobank resource. The initiative will enable researchers ... of new medicines for a wide range of serious and ... ...
(Date:3/22/2017)... , March 22, 2017 Oramed Pharmaceuticals ... www.oramed.com ), a clinical-stage ... drug delivery systems, announced today that Dr. ... deliver a presentation titled, "Oral Insulin for Diabetes ... Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics (OPT) Boston Conference ...
(Date:3/22/2017)... --  Boston Biomedical , an industry leader in the ... stemness pathways, today announced its Board of Directors has ... Officer, effective April 24, 2017. Ms. ... FACP, who has led Boston Biomedical since he founded ... Biomedical has grown from a "garage startup" without technology ...
Breaking Biology Technology:
Cached News: