HOME >> BIOLOGY >> NEWS
The Liver's Secret Of Regeneration

THE liver is the body's "comeback kid", capable of amazing feats of regeneration. But biologists in Pennsylvania have now found that the key to the organ's miraculous ability to repair itself could be cells migrating from bone marrow.

Even if two-thirds of a rat's liver is rem-oved, the organ will grow back to normal size within a week. This incredible regeneration is partly due to the unusual ability of specialised liver cells, or hepatocytes, to keep dividing. But the organ repairs itself even in animals given drugs to prevent this occurring, which shows that other cell types must be involved.

The first clues to the identity of these liver stem cells came in the 1950s, from studies of tumours that grow from another type of cell found in the liver, called oval cells. These cancers contain some cells that look like mature hepatocytes and others that resemble the cells that line the bile duct, which deposits the liver's waste products into the intestine. This suggests that the elusive liver stem cells first give rise to the oval cells, which then divide and differentiate to form hepatocytes and bile duct cells.

Last year, Bryon Petersen and his colleagues at the University of Pittsburgh discovered that oval cells have a "marker" molecule on their surfaces that is also found on haematopoietic stem cells-the cells in our bone marrow that give rise to blood cells. Now, with colleagues at McGill University in Quebec, they have proved that cells from bone marrow can indeed form hepatocytes, bile duct cells and oval cells.

The researchers irradiated mice to des-troy their bone marrow and then replaced it with marrow grafts from other animals whose cells could easily be traced. In one experiment, for example, they gave bone marrow grafts from males to female mice. Then they damaged each animal's liver and waited for it to regenerate. When it had done so, some hepatocytes, oval cells and bile duct cells in the repaired orga
'"/>

Contact: Claire Bowles
claire.bowles@rbi.co.uk
44-171-331-2751
New Scientist
28-Apr-1999


Page: 1 2

Related biology news :

1. Secretary of Energy announces seven E.O. Lawrence Award Winners
2. Former US Secretary of the Interior Bruce Babbitt to speak at science symposium
3. Secret behind hard exoskeletons, spreading wings revealed
4. Francis Collins and Ari Patrinos receive Energy Secretarys Gold Award for Human Genome Project
5. UC Riversides Brian Federici receives Secretarys Annual Honor Award from USDA
6. Secrets of drug resistance in bacteria
7. Secretary Abraham announces next steps for artificial retina project
8. Multilateral Initiative on Malaria Secretariat to move to Sweden
9. Secret channel holds key to metabolic mysteries
10. Secrets hidden in a tigers paralyzing roar
11. Secret to Listerias virulence provides clues to workings of other deadly intracellular pathogens, UC Berkeley scientists report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2018)... ... 23, 2018 , ... Clinical laboratories have increasingly adopted LC-MS/MS ... commonly used analytical techniques. However, implementation can be daunting due to the complex ... methods that must be undertaken by the laboratory if they are laboratory developed ...
(Date:8/23/2018)... ... ... is an eight-year-old mini Australian shepherd and a tripod. When Mandy was four years old, ... to try to repair the leg and each time it was unsuccessful. Once she ... with her veterinarian, decided to amputate. With only one front leg, mobility in Mandy’s ...
(Date:8/23/2018)... SAN DIEGO (PRWEB) , ... August 22, 2018 , ... Lajollacooks4u is proud to have ... a second or third time. Companies, such as Illumina, Qualcomm, Hewlett Packard, Sequenom and ... to bond with their teams. , Part of the reason clientele return is ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... , ... August 28, 2018 , ... ... retailer of contact lenses, has been ranked in 1138th place on the 27th ... companies. , The list represents the most successful companies within the American ...
(Date:8/26/2018)... ... August 23, 2018 , ... LabRoots , ... from around the world, will host the 4th Annual Microbiology and Immunology Virtual ... and disciplines, encompassing various research areas including medicine, agriculture, and space. , ...
(Date:8/21/2018)... ... August 21, 2018 , ... ... device compliance and commercialization, has just released a new paper discussing systems ... by Dr. Mario Kossmann, ESEP at the 28th Annual INCOSE International Symposium, ...
(Date:8/17/2018)... (PRWEB) , ... August 16, 2018 , ... ... testing, announced their results from the AmbryShare project were published today in JAMA ... in the largest exome study ever conducted. , Every year hereditary breast cancer ...
Breaking Biology Technology:
Cached News: