The Origins Of Hereditary Breast Cancer -- Studies With Knock-Out Mice Reveal Underlying Mechanisms

Approximately 43,000 women are afflicted with breast cancer every year in Germany. Breast cancer is the predominant type of cancer in women. Almost 10% of breast cancers are known to be due to hereditary alterations of the germ line. Dr Kay-Uwe Wagner, a research grant holder of the Deutsche Forschungsgemeinschaft (DFG), is a member of a group of scientists led by Chu-Xia Deng and Lothar Hennighausen at the National Institutes of Health (NIH). By using an animal model this group has now elucidated the mechanism underlying hereditary breast cancer. The results of their studies with genetically modified mice will be reported in the May issue the scientific journal Nature Genetics.

It has been known for some time that mutations within the BRCA-1 gene play an essential role in the generation of breast cancer and a variety of other cancer types. In its normal state this gene carries out important functions within the cell. What was not known so far was an explanation for the occurrence of tumours when the gene ceases to function.

In extensive studies carried out over a period of three years Deng's group tried to find out how tumours evolve. Kay-Uwe Wagner and his colleagues generated mice harbouring a mutated non-functional BRCA-1 gene in the mammary gland cells while the gene remained functional in all other body cells. This was achieved by making use of special genes that can be utilised like 'molecular scissors' recognising and cleaving segments of the mouse genome. Rodents treated in this way are known as 'knock-out' mice because a specific gene has been inactivated (knocked-out) specifically.

One fifth of the mice that had their BRCA-1 gene removed from the mammary gland cells developed a tumour within one year. The scientists noted that another gene, the p53 gene, had also become altered in these tumours. The p53 gene has been known for some time to be involved also in the generation of cancers. Thus the researchers generated 'double knock-out' mic

Contact: Dr. Kay-Uwe Wagner
Deutsche Forschungsgemeinschaft

Page: 1 2

Related biology news :

1. Gift creates KSU Human Origins Study Institute
2. Origins of modern behavior might be linked to population pressures
3. Origins of first Americans
4. Research Describes Human Origins Debate Before Darwin
5. Little-Explored African Genetic Diversity May Hold Key To Human Origins, Medical Questions
6. Symposium Explores Neandertal Question, Mystery Of Human Origins
7. Brain Antibodies Provide New Clues To Origins Of Tourettes
8. DNA Helps Track Origins Of Growing Blight Problem
9. Genes Linked To Early Onset, Location Of Hereditary Colon Cancer
10. Disease Mechanism In Hereditary Dementia Discovered: Treatment Implications Seen For Alzheimers And Other Neurodegenerative Diseases
11. UCSF Researchers Identify Mutations In Gene Causing Hereditary Form Of Childhood Rickets

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... BioFactura, Inc. today announced ... the Joint Science & Technology Office—Chemical and Biological Defense (JSTO-CBD) of the Department ... scale-up a highly efficient mammalian cell culture-based bioprocess suitable to meet surge requirement ...
(Date:7/18/2020)... ... July 17, 2020 , ... Commercial launch readiness is a ... to discover a COVID cure or vaccine, the global economic downturn will only increase ... is not going away and capturing full value from every product launch is critical. ...
(Date:7/2/2020)... ... July 01, 2020 , ... ... 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host ... by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... the life sciences industry, today announced the release of its signature product ... Medical Science Liaisons (MSLs) and other field medical professionals. , Beacon ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver this ... the only technology of its kind on the market and we were pleased that ... protective capacity of traditional cultured ingredients, creating a natural way to extend the shelf ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief ... clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an ...
Breaking Biology Technology:
Cached News: