The area where carcinogens settle may be a key factor in developing lung cancer

(June 10, 2003) Bethesda, MD Environmental particles the size of those emanating from cigarette smoke and toxic aerosols interact with our pulmonary surfaces and may lead to lung disease. The location of such cancerous lesions in the bronchial airway may not be a random process, however. Instead, they may be related to a regional pattern of toxic material deposited in selected areas of the lungs. A new study suggests that a specific site the ridge separating the two halves of the bronchial airway -- may be a key factor in developing lung cancer.


Earlier studies of cell dynamics indicate that benign and cancerous lesions alike predominate at the division between the central airways. One study has assessed the likelihood of finding cancer based on the site within the bronchi as ten percent for the main surface and 30 percent each for the lobar, segmental and subsegmental regions. Later research suggests that the accumulation of carcinogenic particles and particles with absorbed carcinogens from cigarette smoke at the airway's carinas -- the ridge separating the openings of the right and left main bronchi at their junction with the trachea -- is a potentially important mechanism for human pulmonary carcinogenesis. Animal studies indicate that clearing particles is much slower in the airway carinas than in the tubular airway segments.

The methods currently used to calculate exposure to particles do not take into consideration the inhomogeneity of either the deposition of the toxin or the clearance patterns of the site. The reported locations of cancer manifestation are therefore at odds with the calculated dose patterns among human bronchial airways. Accordingly, the enhanced deposition along the carinal ridges has been thought to be a more relevant deposition quantity for assessing risk than is the method of using average deposition patterns. In addition to there being increased deposits in the carcina, the streamline cu

Contact: Donna Krupa
American Physiological Society

Page: 1 2 3 4

Related biology news :

1. New map predicts where wolves will attack
2. Scientists discover where snakes lived when they evolved into limbless creatures
3. Scientists find new way to assess where cotton-killing pests develop
4. Study finds wind, currents play key role where young fish settle
5. Study: living near where pesticides used may boost fetal death due to birth defects
6. Life in the inferno: researchers identify factors that determine where microorganisms can survive in the hellish world deep underground
7. Jefferson researchers find access to new methods of HIV prevention for pregnant women and newborns may depend on where they were receiving care
8. Bugscope Gives Internet Users Anywhere Chance To Study Insects
9. New research supports the link between cooking and carcinogens
10. Advisory panel on federal report on carcinogens makes recommendations to NIEHS/NTP for new listings
11. Suggested changes in federal report on carcinogens to be aired Oct. 21 and 22 at public meeting

Post Your Comments:

(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in ... FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... most effective way to complete one? Will the study comply with all FDA ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... (MBS) has announced a publication detailing the use of its revolutionary NEXTGENPCR ... chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... develop a vaccine or drug treatment. In an effort to better understand the ... released the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry ... its strong opposition to the recently introduced bicameral Facial Recognition and Biometric ... most federal use of nearly all biometric and related image analytics technologies, incorrectly ...
(Date:6/23/2020)... ... 2020 , ... DeCurtis Corporation, the premier provider of location ... has been appointed CEO and President. Founder and former CEO, David DeCurtis, will ... Corporation has been on an incredible journey for the last twenty years, and ...
Breaking Biology Technology:
Cached News: