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The biological clock: What really makes us tick

t cancer drug therapies are metabolized much better at certain times of the day. So, if physicians can pinpoint these ideal times and give those drugs when they do not metabolize and allow the body to clear them naturally, then side effects can be reduced while impact is maximized.

And with such vital signs as blood pressure and heart rate under the control of the circadian clock, respiratory, cardiac and cerebrovascular conditions that are dependent on these vitals also are on the way to being better understood. Asthma attacks, for example, primarily occur in the middle of the night, while peak time for heart attacks and strokes is typically mid morning.

The mystery behind biological clocks also is key to understanding how sleep-wake cycle disruptions lead to various types of depression and may ultimately uncover ways to better cope with shift work and jet lag.

Hardin's enthusiasm for this burgeoning field is obvious and his contributions significant. He was trained as a molecular geneticist, joining the UH faculty in 1995. He has won a number of awards for his research, among them the Aschoff-Honma Prize that he received this September in Japan. The award is presented every two years to a scientist working in the field of biological rhythms and currently carries a monetary award of one million yen (approximately $10,000). Hardin and his team also have grants from the National Institutes of Health, Department of Defense and NASA.


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Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
25-Mar-2004


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