HOME >> BIOLOGY >> NEWS
The catch 22 of immune response to AIDs viral infection

A strong antigen-specific T-cell response to HIV infection is important for controlling virus replication; however, because HIV selectively infects and replicates in CD4 T cells, increased number of these cells in response to viral infection may also be detrimental as these cells provide fuel for the infection to grow.

In the March 15 issue of the Journal of Clinical Investigation, Mark Feinberg and colleagues, of Emory University Vaccine Center, analyze the specific parameters of T-cell activation that may be harmful or helpful in fighting HIV infection by looking at simian immunodeficiency viral (SIV) replication in rhesus macaques where they have blocked CD4 and CD8 T-cell co-stimulation pathways.

The study provides clear evidence for an important role in the immune activation level directly affects the initial peak of virus in the blood stream. They further show that the steady-state viral levels in chronic infection are directly related to the generation of a primary immune response.

Evidence in this study also indicates, indirectly, that immunological response may indeed be harmful by providing increased numbers of target cells for infection. The work here presents the first set of data to differentiate between helpful and harmful effects of the immune response to HIV, and may therefore contribute to new strategies for combating this disease.

An accompanying commentary by Bruce Walker (Harvard Medical School) and Steven Deeks (University of California, San Francisco) provides a detailed discussion of the different components of the findings and how these results aid in picking apart this complex interplay between HIV infection and our immune response.


'"/>

Contact: Laurie Goodman
lgoodman@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2004


Page: 1

Related biology news :

1. Study in Science reveals recreational fishing takes big bite of ocean catch
2. DNA chip will catch beefed up chicken
3. Bucket with two ears catches DNA
4. Controlling cell adhesion: Researchers report first evidence of catch bonds
5. Synchronised swimming helps catch prey
6. Clinical services must catch up
7. Hot polymer catches carbon dioxide better
8. North Atlantic study reveals food fish catches have declined by half - despite tripled fishing effort
9. California gnatcatcher: Umbrella species failure?
10. Scientists catch "molecular snapshot" of COX-2 in action
11. Scientists discover how cells catch a cold

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: The catch immune response AIDs viral infection

(Date:11/5/2014)... professor of biology in the UTSA College of ... nation selected to receive a two-year $300,00 National ... Research (EAGER). The funding supports President Obama,s BRAIN ... create new technology that will demystify complex brain ... in neuroscience are broken into the interactions of ...
(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... , Nov. 4, 2014   Neurotechnology , ... announced that the latest version of its fingerprint ... Ongoing MINEX evaluation organized by NIST. ... algorithms using the INCITS 378 fingerprint standard template ... in public tenders in the United ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
(Date:11/26/2014)... (PRWEB) November 26, 2014 PMG Research, ... Board. PMG Research is a network of sites that provide ... to over 2 million patient lives through its partnerships with ... comprised of 11 hub site locations in the Southeastern United ... first term of the board will be held ...
(Date:11/26/2014)... 25, 2014 Silicon Valley Electronic Data ... RPM Alliance , provider of clinical research and ... the latest addition to its CRO Partnership Program, Clinovo ... system to India. , “We have found Clinovo’s ... customizable EDC platform which is both user friendly and ...
(Date:11/26/2014)... Global biostimulants market is expected to ... estimated CAGR of 12.5%. In order to cater ... least ecological impacts, farmers are looking to adopt ... yield more effectively & efficiently. Biostimulants are consequently ... return on investments. , Leading companies in the ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 CURE™ ... recognition reception on December 5, 2014, in San Francisco ... The MPN Heroes event will honor clinicians, caregivers, and ... of myeloproliferative neoplasms (MPNs). , Special guest speaker ... his family's cancer journey at the reception. Over ...
Breaking Biology Technology:PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4
Cached News: